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多组学分析比较阳性和阴性胃癌。

Comparison of positive and negative gastric cancer via multi-omics analysis.

机构信息

Department of Medical Oncology, Nanyang Central Hospital, Nanyang, Henan, China.

Department of Digestive Surgical Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

mBio. 2023 Dec 19;14(6):e0153123. doi: 10.1128/mbio.01531-23. Epub 2023 Oct 17.

DOI:10.1128/mbio.01531-23
PMID:37846989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10746152/
Abstract

This is the first clinical research to systematically expound the difference between gastric cancer (GC) individuals with and GC individuals without from the perspective of multi-omics. This clinical study identified significant genes, microbes, and fecal metabolites, which exhibited nice power for differentiating GC individuals with infection from GC individuals without infection. This study provides a crucial basis for a better understanding of eradication therapy among the GC population.

摘要

这是第一项从多组学角度系统阐述胃癌（GC）合并和不合并幽门螺杆菌（）个体差异的临床研究。本临床研究鉴定了具有良好区分 GC 合并和不合并感染个体能力的显著基因、微生物和粪便代谢物。该研究为更好地了解 GC 人群的根除治疗提供了重要基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/b120585b3473/mbio.01531-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/5675546acc4c/mbio.01531-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/ec802fb78cbd/mbio.01531-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/6d397d3144d9/mbio.01531-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/d552106139dc/mbio.01531-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/bbecde2082e9/mbio.01531-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/b120585b3473/mbio.01531-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/5675546acc4c/mbio.01531-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/ec802fb78cbd/mbio.01531-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/6d397d3144d9/mbio.01531-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/d552106139dc/mbio.01531-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/bbecde2082e9/mbio.01531-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/10746152/b120585b3473/mbio.01531-23.f006.jpg

相似文献

[1]
Comparison of positive and negative gastric cancer via multi-omics analysis.

mBio. 2023-12-19

[2]
Association Between Gut Microbiota and -Related Gastric Lesions in a High-Risk Population of Gastric Cancer.

Front Cell Infect Microbiol. 2018-6-19

[3]
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[4]
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[5]
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[6]
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[7]
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Gastric Cancer. 2021-5

[8]
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[9]
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[10]
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引用本文的文献

[1]
Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice.

Biol Sex Differ. 2025-2-21

[2]
Effect of -induced gastric cancer on gastrointestinal microbiota: a narrative review.

Front Oncol. 2025-1-10

[3]
The oncogenic role and prognostic value of PXDN in human stomach adenocarcinoma.

BMC Cancer. 2024-11-28

[4]
Identifying and validating the roles of the cuproptosis-related gene DKC1 in cancer with a focus on esophageal carcinoma.

J Cancer Res Clin Oncol. 2024-8-5

[5]
Analysis of metabolic characteristics of metabolic syndrome in elderly patients with gastric cancer by non-targeted metabolomics.

World J Gastrointest Oncol. 2024-6-15

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