急性髓细胞白血病的免疫治疗靶点。
Immunologic Targets in AML.
机构信息
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
出版信息
Blood Cancer Discov. 2023 Nov 1;4(6):430-432. doi: 10.1158/2643-3230.BCD-23-0161.
Abstract
In this issue of Blood Cancer Discovery, Nelde and colleagues used a sensitive mass spectrometry-based immunopeptidomics approach to characterize the antigenic landscape of acute myeloid leukemia (AML) and were able to identify immunogenic peptides presented by both leukemia stem cells (LSC) and bulk primary AML blasts. These immunogenic peptides elicit primarily CD4 T-cell responses and the diversity of the HLA class II immunopeptidome and presence of CD4 memory T-cell responses were both associated with improved clinical outcome. See related article by Nelde et al., p. 468 (1) .
摘要
在本期《Blood Cancer Discovery》中，Nelde 及其同事采用了灵敏的基于质谱的免疫肽组学方法来描绘急性髓细胞白血病（AML）的抗原图谱，并能够鉴定由白血病干细胞（LSC）和原发性 AML 原始细胞共同呈递的免疫原性肽。这些免疫原性肽主要引发 CD4 T 细胞反应，HLA Ⅱ类免疫肽组的多样性和 CD4 记忆 T 细胞反应的存在均与改善的临床结局相关。请参见 Nelde 等人的相关文章，第 468 页（1）。
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本文引用的文献
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Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells.急性髓系白血病的免疫监视由白血病祖细胞上 HLA 呈递的抗原介导。
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2
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