Chou Yian-Lin, Ling Wei-Sheng, Chiou Yih-Hwa
Department of Neurology, Far Eastern Memorial Hospital.
Acta Neurol Taiwan. 2024 Jun 30;33(2):81-85.
Vaccine-induced immune thrombotic thrombocytopenia (VITT), also known as thrombosis with thrombocytopenia syndrome, is a rare complication of ChAdOx1 nCoV-19 (AZD1222) vaccine administration. The overall incidence of VITT worldwide is one case per 100 000 exposures. Because of the high mortality rate from VITT, thorough monitoring is crucial to predict the risk of occurrence. The underlying risk factors for VITT are not fully understood. Potential risk factors include sex (female) and young age (less than 50 years), but further research must be conducted to confirm these assumptions. We report the case of a woman with obesity, which is a risk factor for deep vein thrombosis in the legs and for pulmonary embolism, who experienced fulminant VITT after AZD1222 vaccine administration. Keywords: Vaccine-induced immune thrombotic thrombocytopenia, AZ vaccine, Obesity, Risk factor.
疫苗诱导的免疫性血栓性血小板减少症（VITT），也称为伴有血小板减少症的血栓形成综合征，是接种ChAdOx1 nCoV-19（AZD1222）疫苗后的一种罕见并发症。全球范围内VITT的总体发病率为每10万次接种出现1例。由于VITT的死亡率很高，进行全面监测对于预测发病风险至关重要。VITT的潜在危险因素尚未完全明确。潜在危险因素包括性别（女性）和年轻（小于50岁），但必须开展进一步研究以证实这些推测。我们报告了一例肥胖女性的病例，肥胖是下肢深静脉血栓形成和肺栓塞的危险因素，该女性在接种AZD1222疫苗后发生了暴发性VITT。关键词：疫苗诱导的免疫性血栓性血小板减少症、AZ疫苗、肥胖、危险因素
