Diabetic Foot Section - Pisa University Hospital, Via Paradisa 2, 56126, Pisa, Italy.
Acta Diabetol. 2024 Feb;61(2):245-251. doi: 10.1007/s00592-023-02188-8. Epub 2023 Oct 17.
Anemia has been associated with severity of diabetic foot (DF) disease. Our study aimed to evaluate whether the presence of anemia could decrease the healing chances in DF.
We retrospectively analyzed all patients admitted in our department in 2021 for DF, dividing them according to presence (Group A) or absence (Group B) of anemia. Groups were compared for clinical and demographic characteristics, procedures and outcomes: healing rate (HR) at 6 months, healing time (HT) and recurrence rate (RR) at 12 months.
We sorted out data from 196 consecutive patients: 114 (58%) in Group A and 82 (42%) in B. Group A had a higher male prevalence and a longer duration of disease. Group A showed lower hemoglobin concentration (10.3 ± 1.3 g/dL vs 13.1 ± 1.4 g/dL, p < 0.002) and red blood cells count (3.4 ± 0.5 × 10/mL vs 4.8 ± 0.6 × 10/mL, p = 0.004). Group A presented a lower HR (55.2% vs 76.8%, p = 0.0028), no differences in HT and a higher RR (23.6% vs 17.1%, p < 0.02). Cox's logistic regression on healing confirmed the negative impact of anemia: hazard ratio 2.8 (CI 95% 1.4-5.4, p = 0.0037).
Anemia is frequent in DF and associates to a reduction in healing chances and an increase in recurrences representing an independent predictor of healing failure.
贫血与糖尿病足（DF）疾病的严重程度相关。本研究旨在评估贫血是否会降低 DF 的愈合机会。
我们回顾性分析了 2021 年在我院住院的所有 DF 患者，根据是否存在贫血（A 组）将其分为两组。比较两组的临床和人口统计学特征、治疗方法和结局：6 个月时的愈合率（HR）、愈合时间（HT）和 12 个月时的复发率（RR）。
我们整理了 196 例连续患者的数据：A 组 114 例（58%），B 组 82 例（42%）。A 组男性患病率较高，疾病持续时间较长。A 组血红蛋白浓度（10.3±1.3 g/dL 比 13.1±1.4 g/dL，p<0.002）和红细胞计数（3.4±0.5×10/mL 比 4.8±0.6×10/mL，p=0.004）较低。A 组 HR 较低（55.2%比 76.8%，p=0.0028），HT 无差异，但 RR 较高（23.6%比 17.1%，p<0.02）。对愈合的 Cox 逻辑回归证实了贫血的负面影响：危险比 2.8（95%CI 1.4-5.4，p=0.0037）。
贫血在 DF 中很常见，与愈合机会减少和复发增加有关，是愈合失败的独立预测因素。
