Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Razi Drug Research Centre, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2023 Dec;50(12):10409-10425. doi: 10.1007/s11033-023-08859-7. Epub 2023 Oct 18.
Tryptophan metabolism along the kynurenine pathway is of central importance for the immune function. It prevents hyperinflammation and induces long-term immune tolerance. Accumulating evidence also demonstrates cytoprotective and immunomodulatory properties of kynurenine pathway in conditions affecting either central or peripheral nervous system as well as other conditions such as inflammatory bowel disease (IBD). Although multilevel association exists between the inflammatory bowel disease (IBD) and various neurologic (e.g., neurodegenerative) disorders, it is believed that the kynurenine pathway plays a pivotal role in the development of both IBD and neurodegenerative disorders. In this setting, there is strong evidence linking the gut-brain axis with intestinal dysfunctions including IBD which is consistent with the fact that the risk of neurodegenerative diseases is higher in IBD patients. This review aims to highlight the role of kynurenine metabolic pathway in various neurologic and psychiatric diseases as well as relationship between IBD and neurodegenerative disorders in the light of the kynurenine metabolic pathway.
色氨酸代谢沿犬尿氨酸途径对免疫功能至关重要。它可以防止过度炎症并诱导长期免疫耐受。越来越多的证据还表明，犬尿氨酸途径在影响中枢或外周神经系统的疾病以及其他疾病（如炎症性肠病（IBD））中具有细胞保护和免疫调节特性。尽管炎症性肠病（IBD）与各种神经（例如神经退行性）疾病之间存在多层次关联，但据信犬尿氨酸途径在 IBD 和神经退行性疾病的发展中起关键作用。在这种情况下，有强有力的证据表明肠道-大脑轴与包括 IBD 在内的肠道功能障碍有关，这与 IBD 患者患神经退行性疾病的风险更高的事实是一致的。鉴于犬尿氨酸代谢途径，本综述旨在强调犬尿氨酸代谢途径在各种神经和精神疾病中的作用，以及 IBD 和神经退行性疾病之间的关系。
