Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Research School GROW, Maastricht University Medical Centre, Maastricht, The Netherlands.
BJOG. 2024 May;131(6):777-785. doi: 10.1111/1471-0528.17688. Epub 2023 Oct 18.
To investigate whether women with unexplained recurrent pregnancy loss have impaired arterial vascular health compared with controls, and to evaluate whether this is modifiable by exercise.
Experimental case-control pilot study.
University medical centre in the Netherlands.
Twelve women with unexplained recurrent pregnancy loss, 11 nulliparous women and 19 primiparous women with a history of uncomplicated pregnancies.
In all three groups we measured baseline characteristics, metabolic components and arterial vascular health, and repeated this in women with unexplained recurrent pregnancy loss after 1 month of protocolled and supervised cycle training.
Differences in arterial vascular health between women with unexplained recurrent pregnancy loss and controls, and the effect of exercise on arterial vascular health in women with unexplained recurrent pregnancy loss.
Women with unexplained recurrent pregnancy loss have a significantly increased carotid intima media thickness in comparison with both controls (both P < 0.01), a significantly decreased brachial endothelial dependent flow-mediated vasodilation in comparison with both controls (nulliparous: P < 0.01; primiparous: P = 0.05) and a significantly decreased femoral endothelial dependent flow-mediated vasodilation in comparison with primiparous women (P = 0.01). The endothelium independent glyceryl trinitrate response was similar in all groups. With 1 month of exercise, the carotid intima media thickness decreased significantly by 7% (P = 0.05) and the femoral FMD increased significantly by 10% (P = 0.01) in women with unexplained recurrent pregnancy loss.
Women with unexplained recurrent pregnancy loss have an impaired vascular health in comparison with controls. This impaired arterial vascular health can be improved by exercise.
研究原因不明复发性妊娠丢失的女性与对照组相比是否存在动脉血管健康受损，并评估运动是否可以改善这种情况。
实验性病例对照初步研究。
荷兰的一所大学医学中心。
12 名原因不明复发性妊娠丢失的女性、11 名未生育的女性和 19 名生育过无并发症妊娠的初产妇。
在所有三组中，我们测量了基线特征、代谢成分和动脉血管健康，并在原因不明复发性妊娠丢失的女性中，在经过 1 个月的方案和监督的循环训练后，重复这些测量。
原因不明复发性妊娠丢失的女性与对照组之间的动脉血管健康差异，以及运动对原因不明复发性妊娠丢失的女性动脉血管健康的影响。
与对照组相比，原因不明复发性妊娠丢失的女性颈动脉内膜中层厚度明显增加（均 P<0.01），与对照组相比，肱动脉内皮依赖性血流介导的血管舒张功能明显降低（未生育：P<0.01；初产妇：P=0.05），与初产妇相比，股动脉内皮依赖性血流介导的血管舒张功能明显降低（P=0.01）。各组之间的内皮非依赖性甘油三酯反应相似。经过 1 个月的运动，原因不明复发性妊娠丢失的女性颈动脉内膜中层厚度显著降低 7%（P=0.05），股动脉 FMD 显著增加 10%（P=0.01）。
与对照组相比，原因不明复发性妊娠丢失的女性血管健康受损。这种受损的动脉血管健康可以通过运动得到改善。
