色胺类与心理健康：激活5-羟色胺受体以挖掘治疗潜力。
Tryptamines and Mental Health: Activating the 5-HT Receptor for Therapeutic Potential.
作者信息
Kargbo Robert B
机构信息
Usona Institute, Fitchburg, Wisconsin 53711-5300, United States.
出版信息
ACS Med Chem Lett. 2023 Sep 15;14(10):1331-1333. doi: 10.1021/acsmedchemlett.3c00390. eCollection 2023 Oct 12.
Tryptamines, a class of 3-aminoethyl-indoles that activate the serotonin receptor, show potential for novel mental health treatments. The FDA has granted "breakthrough therapy designation" to psilocybin and MDMA for treatment-resistant depression, major depressive disorder, and post-traumatic stress disorder, sparking global research efforts. Various clinical trials are currently investigating the therapeutic value of psilocybin for several mental health disorders. Results thus far indicate significant improvements in patient-reported outcomes via reductions in experiential avoidance. These advancements highlight a promising future for tryptamines in mental health therapy.
色胺类物质是一类能激活血清素受体的3-氨基乙基吲哚，在新型心理健康治疗方面显示出潜力。美国食品药品监督管理局（FDA）已授予裸盖菇素和摇头丸“突破性疗法认定”，用于治疗难治性抑郁症、重度抑郁症和创伤后应激障碍，引发了全球范围的研究热潮。目前，多项临床试验正在探究裸盖菇素对多种心理健康障碍的治疗价值。迄今为止的结果表明，通过减少经验性回避，患者报告的结果有显著改善。这些进展凸显了色胺类物质在心理健康治疗领域的光明前景。
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