Almasary Manal, Alkhalifah Khalid M, Alotaibi Solaf Hilal, Elhefny Mohamed, Alabssi Haila, Alaklabi Sara Saeed, Alayed Rasil Sulaiman, Alghamdi Anwar A, Albalawi Abdulmajeed
Internal Medicine, Umm Al-Qura University, Al Qunfudhah, SAU.
Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, SAU.
Cureus. 2023 Sep 16;15(9):e45357. doi: 10.7759/cureus.45357. eCollection 2023 Sep.
Irritable bowel syndrome (IBS) is a commonly found global functional pathology with no detectable structural changes. It affects the quality of life and often coexists with psychiatric and somatic issues. We reviewed all articles published between 1990 and April 2023. The databases used for the data search were Google Scholar, Web of Science, Cochrane Library, and PubMed/MEDLINE. Ovid search engine was also used to broaden the search strategy. Predefined keywords, including "Irritable bowel syndrome" (MeSH) OR "IBS" (all fields), along with "Saudi Arabia" and "Middle East," were used to avoid data loss and ambiguity. Any cross-sectional study that reported the prevalence of IBS in any gender, age, and group of the Saudi population was included. Data extraction was independently performed in duplicate to mitigate bias and data loss. Statistical analysis of proportion was conducted by using Miller (Freeman-Tukey double arcsine - exact inverse). Out of 350 records identified, only 38 studies were included in the quantitative synthesis. The total number of study participants was 26,567, on the basis of the predefined inclusion criteria of the study. StatsDirect software was used for the statistical analysis of the study parameters. Based on all 38 identified studies, the calculated pooled prevalence was 20.7% (95% confidence interval (CI) = 17.8% to 23.7% by applying random effects (DerSimonian-Laird method). IBS was identified in 21% (95% CI = 16.7% to 25.7%) of the general population, 22% (95% CI = 17.6% to 26.7%) of students, and 18.3% (95% CI = 13.3% to 23.9%) of healthcare workers. The pooled prevalence of IBS among the Saudi population was 20.7%. The pathophysiology of IBS is complexed and significantly affected by genetics, diet, cultural characteristics, age, anxiety, depression, stress, and sleep disorders. This study fills a gap in understanding IBS prevalence in Saudi Arabia, contributing valuable data to this region.
肠易激综合征（IBS）是一种常见的全球性功能性疾病，无明显结构变化。它会影响生活质量，且常与精神和躯体问题并存。我们回顾了1990年至2023年4月发表的所有文章。用于数据检索的数据库有谷歌学术、科学网、考克兰图书馆和PubMed/MEDLINE。还使用了Ovid搜索引擎来拓宽检索策略。使用了预定义关键词，包括“肠易激综合征”（医学主题词）或“IBS”（所有字段），以及“沙特阿拉伯”和“中东”，以避免数据丢失和歧义。纳入任何报告沙特人群中任何性别、年龄和群体的IBS患病率的横断面研究。数据提取独立进行了两次，以减少偏差和数据丢失。采用米勒法（弗里曼 - 图基双反正弦 - 精确倒数）进行比例的统计分析。在识别出的350条记录中，只有38项研究纳入了定量综合分析。根据该研究预先确定的纳入标准，研究参与者总数为26,567人。使用StatsDirect软件对研究参数进行统计分析。基于所有38项已识别的研究，计算得出的合并患病率为20.7%（95%置信区间（CI）= 17.8%至23.7%，采用随机效应（德西蒙尼亚 - 莱尔德法））。在普通人群中，IBS的识别率为21%（95%CI = 16.7%至25.7%），学生中为22%（95%CI = 17.6%至26.7%），医护人员中为18.3%（95%CI = 13.3%至23.9%）。沙特人群中IBS的合并患病率为20.7%。IBS的病理生理学很复杂，受到遗传、饮食、文化特征、年龄、焦虑、抑郁、压力和睡眠障碍的显著影响。本研究填补了对沙特阿拉伯IBS患病率认识的空白，为该地区提供了有价值的数据。
