Research Department, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain.
School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain.
Front Endocrinol (Lausanne). 2023 Oct 2;14:1270949. doi: 10.3389/fendo.2023.1270949. eCollection 2023.
Polychlorinated biphenyls (PCBs) are organic lipophilic pollutants that accumulate in the body. Previous research has linked PCBs with menstrual function; therefore, this study was undertaken to investigate the correlation of PCBs with luteal phase hormonal parameters of menstrual function at day 21 in a group of non-obese women prior to fertilization (IVF).
Fifty-eight non-obese Caucasian women from a UK academic center, 29 with polycystic ovary syndrome (PCOS) and 29 without, were recruited. PCOS women all had anovulatory infertility. Non-PCOS women: five with unexplained infertility, the remainder with male factor infertility (n=14) or tubal problems (n=10). Blood was withdrawn at day 21 of the menstrual cycle for non-PCOS women, at the time of mock embryo transfer. PCBs were measured using high resolution gas chromatography.
Only PCB118, PCB153, PCB138 and PCB180 were detected in all samples, and levels did not differ between PCOS and non-PCOS subjects. In non-PCOS subjects, PCB153, PCB138 and PCB180 inversely correlated with estradiol (p<0.05); PCB118 and PCB138 inversely correlated with follicle stimulating hormone (FSH) (p<0.05); PCB118 (p<0.05), PCB153, PCB138 and PCB180 (all p<0.01) inversely correlated with luteinizing hormone (LH). Control women without PCOS with unexplained infertility showed higher levels of PCB118, PCB153, PCB138 and PCB180 (p<0.05) compared to those control women without PCOS with tubal or male factor infertility, though other hormonal parameters did not differ other than that FSH that was lower in the unexplained group (p=0.01). The only correlation observed in PCOS women with anovulatory infertility was that between PCB180 and progesterone (p<0.05).
PCBs correlated with luteal phase menstrual cycle hormones in control women without PCOS and may contribute to the mechanism of unexplained infertility; in PCOS women, no correlations of the PCBs were seen for estradiol, LH or FSH.
多氯联苯（PCBs）是一种有机脂溶性污染物，会在体内蓄积。先前的研究表明 PCBs 与月经功能有关；因此，本研究旨在调查一组非肥胖女性在接受体外受精（IVF）前的黄体期第 21 天月经功能的黄体期激素参数与 PCBs 的相关性。
从英国学术中心招募了 58 名非肥胖的白种女性，其中 29 名患有多囊卵巢综合征（PCOS），29 名没有。患有 PCOS 的女性均患有排卵障碍性不孕。非 PCOS 女性：五名患有不明原因不孕，其余患有男性因素不孕（n=14）或输卵管问题（n=10）。非 PCOS 女性在月经周期的第 21 天采血，PCOS 女性在模拟胚胎移植时采血。使用高分辨率气相色谱法测量 PCBs。
仅在所有样本中检测到 PCB118、PCB153、PCB138 和 PCB180，且 PCOS 和非 PCOS 受试者之间的水平没有差异。在非 PCOS 受试者中，PCB153、PCB138 和 PCB180 与雌二醇呈负相关（p<0.05）；PCB118 和 PCB138 与卵泡刺激素（FSH）呈负相关（p<0.05）；PCB118（p<0.05）、PCB153、PCB138 和 PCB180（均 p<0.01）与黄体生成素（LH）呈负相关。非 PCOS 不明原因不孕的对照组女性与非 PCOS 输卵管或男性因素不孕的对照组女性相比，PCB118、PCB153、PCB138 和 PCB180 水平更高（p<0.05），但除了不明原因组的 FSH 较低（p=0.01）外，其他激素参数没有差异。排卵障碍性不孕的 PCOS 女性唯一观察到的相关性是 PCB180 与孕激素之间的相关性（p<0.05）。
PCBs 与非 PCOS 对照组女性黄体期月经周期激素相关，可能导致不明原因不孕的发生；在 PCOS 女性中，PCBs 与雌二醇、LH 或 FSH 之间没有相关性。
