Department of Veterinary and Animal Sciences University of Copenhagen Frederiksberg Denmark.
Department of Virus and Microbiological Special Diagnostics Statens Serum Institut Copenhagen Denmark.
Influenza Other Respir Viruses. 2023 Oct 15;17(10):e13208. doi: 10.1111/irv.13208. eCollection 2023 Oct.
In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals.
2021 年和 2022 年，在丹麦的一只海豹和一只成年狐狸以及三只幼狐中检测到了 2.3.4.4b 分支的 H5Nx 高致病性禽流感病毒。这些病毒与欧洲同期发现的病毒密切相关，有些病毒获得了与哺乳动物适应相关的氨基酸取代。值得注意的是，感染幼狐中的病毒分布似乎有所不同，其中一只仅在大脑中检测到 HPAIV 的存在，而另外两只仅在肺部检测到。总的来说，这些发现强调了需要加强对野生和养殖哺乳动物疾病的监测。
