Sasaki Nobuo, Ueno Yoshitaka, Ozono Ryoji, Yoshimura Kenichi, Nakano Yukiko, Higashi Yukihito
Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council.
Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University.
J Hypertens. 2024 Feb 1;42(2):292-300. doi: 10.1097/HJH.0000000000003597. Epub 2023 Oct 11.
This study aimed to investigate the relationship between serum uric acid (SUA) levels and hypertension in the middle-aged and elderly populations.
The cross-sectional analysis included 13 349 middle-aged and elderly general health checkup examinees without cardiovascular disease. The retrospective cohort analysis included 6659 normotensive participants (mean age: 64.6 years). Participants were divided into three groups based on their SBP/DBP levels: normal (<120/<80 mmHg), high normal (120-129/<80 mmHg), and elevated (130-139/80-89 mmHg), and were classified into three groups based on the results of 75 g oral glucose tolerance test: normoglycemia, prediabetes, and diabetes.
SUA levels were significantly associated with SBP and DBP in this cross-sectional study. Over a mean 6.5-year follow-up period, 2038 participants developed hypertension. According to the SUA quartiles, the incidence of hypertension increased [26.1% in quartile (Q1) (≤4.1 mg/dl), 28.6% in Q2 (4.2-4.9 mg/dl), 32.6% in Q3 (5.0-5.8 mg/dl), 34.9% in Q4 (≥5.9 mg/dl); P for trend <0.001]. In multivariable analyses, SUA levels were positively associated with hypertension incidence only in the normal BP group [Q4 vs. Q1 odds ratio (OR): 1.64, 95% confidence intervals (CIs): 1.11-2.44; Q3 vs. Q1 OR: 1.69, 95% CI: 1.19-2.42] and in the normoglycemic group (Q4 vs. Q1 OR: 1.34, 95% CI: 1.02-1.76; Q3 vs. Q1 OR: 1.36, 95% CI: 1.07-1.74).
In the middle-aged and elderly populations, normotensive or normoglycemic individuals with SUA levels at least 5 mg/dl may be potential targets for SUA management to prevent hypertension.
本研究旨在调查中老年人群血清尿酸（SUA）水平与高血压之间的关系。
横断面分析纳入了13349名无心血管疾病的中老年普通健康体检者。回顾性队列分析纳入了6659名血压正常的参与者（平均年龄：64.6岁）。参与者根据收缩压/舒张压水平分为三组：正常（<120/<80mmHg）、正常高值（120 - 129/<80mmHg）和升高（130 - 139/80 - 89mmHg），并根据75g口服葡萄糖耐量试验结果分为三组：血糖正常、糖尿病前期和糖尿病。
在这项横断面研究中，SUA水平与收缩压和舒张压显著相关。在平均6.5年的随访期内，2038名参与者患高血压。根据SUA四分位数，高血压发病率增加[四分位数（Q1）（≤4.1mg/dl）为26.1%，Q2（4.2 - 4.9mg/dl）为28.6%，Q3（5.0 - 5.8mg/dl）为32.6%，Q4（≥5.9mg/dl）为34.9%；趋势P<0.001]。在多变量分析中，SUA水平仅在正常血压组[Q4与Q1比值比（OR）：1.64，95%置信区间（CI）：1.11 - 2.44；Q3与Q1 OR：1.69，95% CI：1.19 - 2.42]和血糖正常组（Q4与Q1 OR：1.34，95% CI：1.02 - 1.76；Q3与Q1 OR：1.36，95% CI：1.07 - 1.74）中与高血压发病率呈正相关。
在中老年人群中，SUA水平至少为5mg/dl的血压正常或血糖正常个体可能是预防高血压的SUA管理潜在目标。
