University of Jeddah, College of Science, Department of Biology, Jeddah, Saudi Arabia.
Braz J Biol. 2023 Oct 13;83:e272466. doi: 10.1590/1519-6984.272466. eCollection 2023.
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by hippocampal, and cortical neuron deterioration, oxidative stress, and severe cognitive dysfunction. Aluminum is a neurotoxin inducer for cognitive impairments associated with AD. The treatment approaches for AD are unsatisfactory. Boswellia papyrifera and Syzygium aromaticum are known for their pharmacological assets, including antioxidant activity. Therefore, the current study explored the possible mitigating effects of a combination of Boswellia papyrifera and Syzygium aromaticum against aluminum chloride (AlCl3) induced AD. The AD model was established using AlCl3 (100 mg/kg), and the rats were orally administrated with Boswellia papyrifera or Syzygium aromaticum or a combination of them daily for 8 weeks. The Y-maze test was used to test cognition in the rats, while acetylcholinesterase (AChE) and oxidative stress markers were estimated in homogenates of the cerebral cortex and hippocampus. Also, the histopathological examination of the cortex and hippocampus were investigated. The results revealed that administration of either B. papyrifera or S. aromaticum extracts significantly improved the cognitive functions of AD rats, enhanced AChE levels, increased oxidative enzymes levels, including SOD and GSH, and reduced MDA levels in homogenates of the cerebral cortex and hippocampus and confirmed by improvement in histological examination. However, using a combination therapy gave better results compared to a single treatment. In conclusion, the present study provided primary evidence for using a combination of B. papyrifera and S. aromaticum to treat cognitive dysfunction associated with AlCl3 Induced AD by improving the AChE levels and modulating oxidative stress in the brain.
阿尔茨海默病（AD）是最常见的神经退行性疾病，其特征是海马体和皮质神经元退化、氧化应激和严重的认知功能障碍。铝是一种与 AD 相关的认知障碍的神经毒素诱导剂。AD 的治疗方法并不令人满意。乳香和丁香因其具有抗氧化活性等药理学特性而闻名。因此，本研究探讨了乳香和丁香联合使用对氯化铝（AlCl3）诱导的 AD 可能具有的缓解作用。使用 AlCl3（100mg/kg）建立 AD 模型，大鼠每天口服乳香或丁香或两者的混合物 8 周。Y 迷宫测试用于测试大鼠的认知能力，而乙酰胆碱酯酶（AChE）和氧化应激标志物则在大脑皮质和海马体匀浆中进行评估。此外，还对皮质和海马体进行了组织病理学检查。结果表明，给予乳香或丁香提取物均可显著改善 AD 大鼠的认知功能，提高 AChE 水平，增加氧化酶水平，包括 SOD 和 GSH，并降低大脑皮质和海马体匀浆中的 MDA 水平，组织学检查也得到了改善。然而，与单一治疗相比，联合治疗效果更好。总之，本研究为使用乳香和丁香联合治疗由 AlCl3 诱导的 AD 相关认知功能障碍提供了初步证据，通过提高 AChE 水平和调节大脑中的氧化应激来改善认知功能障碍。
