Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pathol Res Pract. 2023 Nov;251:154896. doi: 10.1016/j.prp.2023.154896. Epub 2023 Oct 16.
MicroRNA-328 (miR-328) is an RNA gene that is primarily associated with lung cancer, and its encoding gene is located on 16q22.1. Expression of miR-328 has been observed in lung and esophagus tissues based on RNAseq data. Although several studies have aimed at the detection of miR-328 levels in tumor tissues, there is an obvious discrepancy between the results of these studies. Even in a certain type of cancer, some studies have reported up-regulation of miR-328 in cancerous tissues versus control tissues, while others have reported its down-regulation. This discrepancy might be attributed to different stages/grades of tumor tissues or other clinical characteristics. This review article focuses on the available literature to explore the functions of miR-328 in the development of human carcinogenesis.
MicroRNA-328 (miR-328) 是一种主要与肺癌相关的 RNA 基因，其编码基因位于 16q22.1。基于 RNAseq 数据，miR-328 的表达已在肺和食管组织中观察到。尽管有几项研究旨在检测肿瘤组织中 miR-328 的水平，但这些研究的结果存在明显差异。即使在某种类型的癌症中，一些研究报告了 miR-328 在癌组织与对照组织中的上调，而其他研究则报告了其下调。这种差异可能归因于肿瘤组织的不同阶段/分级或其他临床特征。本文综述了现有文献，探讨了 miR-328 在人类肿瘤发生发展中的功能。
