State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, CAS, Wuhan 430071, China.
College of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, China.
J Agric Food Chem. 2023 Nov 1;71(43):15981-15990. doi: 10.1021/acs.jafc.3c00205. Epub 2023 Oct 18.
Osteoporosis is one of the skeletal degenerative diseases accompanied by bone loss and microstructure disruption. Given that the gut-bone signaling axis highly contributes to bone health, here, dietary isoquercetin (IQ) was shown to effectively improve postmenopausal osteoporosis (PMO) in an ovariectomy (OVX) mouse model through the modulation of the gut-bone cross-talk. An study showed that OVX induced striking disruption of the microbial community, subsequently causing gut leakage and gut barrier dysfunction. As a result, lipopolysaccharide (LPS)-triggered inflammatory cytokines released from the intestine to bone marrow were determined to be associated with bone loss in OVX mice. Long-term dietary IQ effectively improved microbial community and gut barrier function in the OVX mice and thus markedly improved bone loss and host inflammatory status by repressing the NF-κB signaling pathway. An study further revealed that IQ treatments dose-dependently inhibited LPS-induced inflammation and partly promoted the proliferation and differentiation of osteoblasts. These results provide new evidence that dietary IQ has the potential for osteoporosis treatment.
骨质疏松症是一种骨骼退行性疾病，伴随着骨量流失和微观结构破坏。鉴于肠道-骨骼信号轴对骨骼健康有重要贡献，本研究表明，饮食中的异槲皮素（IQ）通过调节肠道-骨骼的相互作用，可有效改善去卵巢（OVX）小鼠模型中的绝经后骨质疏松症（PMO）。一项研究表明，OVX 可显著破坏微生物群落，进而导致肠道渗漏和肠道屏障功能障碍。结果表明，源自肠道并释放至骨髓的脂多糖（LPS）触发的炎症细胞因子与 OVX 小鼠的骨丢失有关。长期饮食 IQ 可有效改善 OVX 小鼠的微生物群落和肠道屏障功能，从而通过抑制 NF-κB 信号通路显著改善骨丢失和宿主炎症状态。一项 研究进一步表明，IQ 处理剂量依赖性地抑制 LPS 诱导的炎症，并部分促进成骨细胞的增殖和分化。这些结果为饮食 IQ 具有治疗骨质疏松症的潜力提供了新的证据。
