Famiyeh Lord, Xu Honghui, Chen Ke, Tang Yu-Ting, Ji Dongsheng, Xiao Hang, Tong Lei, Jia Chunrong, Guo Qingjun, He Jun
Center for Environmental Remediation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China; Department of Chemical and Environmental Engineering, University of Nottingham Ningbo China, 199 Taikang E Rd, Ningbo 315100, China.
Zhejiang Institute of Meteorological Sciences, Hangzhou 310017, China.
Sci Total Environ. 2024 Jan 10;907:167762. doi: 10.1016/j.scitotenv.2023.167762. Epub 2023 Oct 16.
Numerous studies have extensively examined the risk of lung cancer associated with polycyclic aromatic hydrocarbons (PAHs), with particular emphasis on the 16 priority PAHs. However, this may underestimate the actual risk. This study seeks to enhance the current risk assessment framework by integrating four additional parent PAHs such as Dibenzo[a,h]pyrene, Dibenzo[a,l]pyrene, Dibenzo[a,e]pyrene, 7H-benzo[c]fluorene with potentially high risk of causing cancer. By considering their physicochemical properties, metabolism, and bioavailability, the study also examines the relationship between low molecular weight (LMW) - and high molecular weight (HMW)-PAH doses and the risk of developing cancer in the human lungs. The study was conducted in Ningbo, China and identified five PAH sources: natural gas combustion (NGC), vehicular exhaust (VE), coal combustion (CC), biomass burning (BB), and volatilization of unburnt fuel (VUF). This study emphasizes the elevated risk associated with highly carcinogenic PAHs, as they consistently exceed acceptable limits for lung cancer risk throughout the year. Based on the study's estimation, approximately 324 out of every one million individuals exposed to PAHs face an increased cancer risk over their lifetime. This research emphasizes the importance of identifying source specific lung cancer risk in residential areas to protect the exposed population. Moreover, while there is a moderate connection between LMW-PAH doses and lung cancer risk, a strong relationship is observed with HMW-PAHs.
众多研究广泛考察了与多环芳烃（PAHs）相关的肺癌风险，尤其着重于16种优先控制的多环芳烃。然而，这可能低估了实际风险。本研究旨在通过纳入另外四种具有潜在高致癌风险的母体多环芳烃，如二苯并[a,h]芘、二苯并[a,l]芘、二苯并[a,e]芘、7H-苯并[c]芴，来完善当前的风险评估框架。通过考虑它们的物理化学性质、代谢和生物利用度，该研究还考察了低分子量（LMW）和高分子量（HMW）多环芳烃剂量与人类肺部患癌风险之间的关系。该研究在中国宁波开展，识别出五种多环芳烃来源：天然气燃烧（NGC）、汽车尾气排放（VE）、煤炭燃烧（CC）、生物质燃烧（BB）以及未燃烧燃料挥发（VUF）。本研究强调了与高致癌性多环芳烃相关的风险升高，因为它们全年始终超过肺癌风险的可接受限值。根据该研究的估计，每百万接触多环芳烃的个体中约有324人在其一生中面临患癌风险增加的情况。这项研究强调了识别居民区特定来源肺癌风险以保护受暴露人群的重要性。此外，虽然低分子量多环芳烃剂量与肺癌风险之间存在适度关联，但与高分子量多环芳烃之间观察到了强烈的关系。
