Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Contact Dermatitis. 2024 Feb;90(2):134-142. doi: 10.1111/cod.14445. Epub 2023 Oct 18.
Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.
To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.
A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.
Of all 4192 patients, 1851 had at least one positive PT reaction. Of these, 410 (22.2%) had MCAs, significantly related to a higher age (p-value = 0.003). Patients with an exclusively positive reaction to linalool HPs but not limonene HPs were shown to have MCAs (p-value <0.001, odds ratio (95% confidence interval) = 4.15 (3.01-5.73)). Patients with simultaneous contact allergies to both linalool and limonene HPs had contact allergies to many other screening and fragrance allergens.
Simultaneous positive PT reactions to allergens in baseline series and fragrances are common in patients with the HPs contact allergy, especially linalool HPs. The pattern of simultaneous PT reactions principally suggested the co-sensitization of the cosmetic allergens.
芳樟醇和柠檬烯过氧化物（HPs）的接触过敏率有所增加。
展示对芳樟醇和/或柠檬烯 HPs 过敏的患者同时出现阳性斑贴试验（PT）反应的模式和多重接触过敏（MCAs）的流行率。
对 2015 年至 2020 年连续就诊的皮炎患者进行回顾性分析。
在所有 4192 名患者中，有 1851 名至少有一个阳性 PT 反应。其中，410 名（22.2%）有 MCAs，与年龄较高显著相关（p 值=0.003）。仅对芳樟醇 HP 而不对柠檬烯 HP 呈阳性反应的患者也显示出 MCAs（p 值<0.001，优势比（95%置信区间）=4.15（3.01-5.73））。同时对芳樟醇和柠檬烯 HPs 均有接触过敏的患者对许多其他筛查和香料过敏原也有接触过敏。
对基础系列和香料中过敏原的同时阳性 PT 反应在 HP 接触过敏的患者中很常见，尤其是芳樟醇 HP。同时出现 PT 反应的模式主要表明了化妆品过敏原的共同致敏。
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