Department of Dermatology, Hospital del Mar, Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona (UAB), 08003 Barcelona, Spain.
Department of Dermatology, University Hospital Virgen Macarena, 41009 Sevilla, Spain.
Contact Dermatitis. 2017 Feb;76(2):74-80. doi: 10.1111/cod.12714. Epub 2016 Nov 29.
Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens.
To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients.
Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain.
Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5-1.9%) and doubtful reactions (0.4-0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested.
Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.
柠檬烯和芳樟醇是常用的香精萜烯，广泛应用于化妆品、家庭和卫生产品。它们在空气中暴露后的主要氧化产物——氢过氧化物，已被认为是重要的接触变应原。
调查在西班牙接触柠檬烯氢过氧化物（Lim-OOHs）和芳樟醇氢过氧化物（Lin-OOHs）的过敏反应的流行情况，并确定连续患者筛查的最佳浓度。
在西班牙的 22 个皮肤科部门，对 3639 例连续患者同时测试了三种不同浓度的 Lim-OOHs（0.1%、0.2%和 0.3% pet.）和 Lin-OOHs（0.25%、0.5%和 1.0% pet.）。
Lim-OOHs 在 0.1%、0.2%和 0.3%的浓度下，阳性斑贴试验反应率分别为 1.4%、3.4%和 5.1%；Lin-OOHs 在 0.25%、0.5%和 1.0%的浓度下，阳性斑贴试验反应率分别为 1.3%、2.9%和 4.9%。在测试的最高浓度下，两种萜烯氢过氧化物仅有少数（1.5-1.9%）刺激性和可疑（0.4-0.5%）反应。
Lim-OOHs 和 Lin-OOHs 可被视为接触过敏的常见原因，因此将其纳入扩展的基线斑贴试验系列似乎是合适的。Lim-OOHs 0.3% pet.和 Lin-OOHs 1.0% pet.的斑贴试验制剂是用于筛选接触致敏的有用工具。
