硝基芘诱导的兔肺分离的克拉拉细胞和II型肺泡细胞中的DNA修复。
Nitropyrene-induced DNA repair in Clara cells and alveolar type-II cells isolated from rabbit lung.
作者信息
Haugen A, Aune T, Deilhaug T
出版信息
Mutat Res. 1986 Dec;175(4):259-62. doi: 10.1016/0165-7992(86)90064-3.
DNA excision repair, as measured by unscheduled DNA synthesis (UDS), was examined in different cell types of rabbit lung exposed to nitropolycyclic aromatic hydrocarbons (NO-PAH) in vitro. Dose-related increases in UDS were observed. 1,6-Dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP) induced UDS more effectively in alveolar type-II cells compared with Clara cells. On the other hand, 1-nitropyrene (1-NP) caused a weak UDS response in Clara cells but no DNA repair in alveolar type-II cells.
通过非预定DNA合成（UDS）来衡量的DNA切除修复，在体外暴露于硝基多环芳烃（NO-PAH）的兔肺不同细胞类型中进行了检测。观察到UDS呈剂量相关增加。与克拉拉细胞相比，1,6-二硝基芘（1,6-DNP）和1,8-二硝基芘（1,8-DNP）在II型肺泡细胞中诱导UDS的效果更明显。另一方面，1-硝基芘（1-NP）在克拉拉细胞中引起微弱的UDS反应，但在II型肺泡细胞中未引起DNA修复。
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