SATB2 基因表观遗传修饰在非综合征性唇腭裂发病机制中的研究进展。

Progress of epigenetic modification of SATB2 gene in the pathogenesis of non-syndromic cleft lip and palate.

机构信息

Department of Plastic Surgery, Meizhou Clinical Institute of Shantou University Medical College, No 63 Huangtang Road, Meizhou, 514031, Guangdong, China.

Department of Plastic Surgery and Burn Center, The Second Affiliated Hospital of Shantou University Medical College, North Dongxia Road, Shantou, 515041, Guangdong, China.

出版信息

Asian J Surg. 2024 Jan;47(1):72-76. doi: 10.1016/j.asjsur.2023.09.113. Epub 2023 Oct 16.

DOI:10.1016/j.asjsur.2023.09.113

PMID:37852859

Abstract

Non-syndromic Cleft Lip and Palate (NSCLP) is one of the most common congenital craniofacial malformations. However, there is no enough knowledge about its mechanism, even through many relevant studies verify that cleft lip and palate is caused by interactions between environmental and genetic factors. SATB2 gene is one of the most common candidate genes of NSCLP, and the development of epigenetics provides a new direction on pathogenesis of cleft lip and palate. This review summarizes SATB2 gene in the pathogenesis of non-syndromic cleft lip and palate, expecting to provide strategies to prevent and treat cleft and palate in the future.

摘要

非综合征性唇腭裂（NSCLP）是最常见的颅面先天畸形之一。然而，尽管许多相关研究证实唇腭裂是由环境和遗传因素相互作用引起的，但人们对其发病机制仍知之甚少。SATB2 基因是 NSCLP 最常见的候选基因之一，表观遗传学的发展为唇腭裂的发病机制提供了新的方向。本文综述了 SATB2 基因在非综合征性唇腭裂发病机制中的作用，以期为未来预防和治疗唇腭裂提供策略。