Department of Animal Science, Universidade de Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal.
Department of Animal Science, Quinta de Prados, Animal and Veterinary Research Center (CECAV), Vila Real, Portugal.
Vet Med Sci. 2023 Nov;9(6):2566-2575. doi: 10.1002/vms3.1285. Epub 2023 Oct 18.
Urinary pH manipulation by therapeutic foods or supplements is part of the treatment for urolithiasis. The effectiveness of these diets and supplements should be studied to determine which of these strategies is most effective.
HYPOTHESIS/OBJECTIVES: To assess the effect of the oral supplementation of potassium citrate, an ammonium chloride solution (Urical) and two dry therapeutic foods-Hill's® Prescription Diet® u/d® Canine (u/d diet) and Royal Canin® Urinary S/O dog (S/O diet)-on a dog's urinary pH at different time points over 8 h.
Seven healthy adult male research beagle dogs.
A prospective interventional study lasting 31 days. The dogs either received a supplement (potassium citrate or rical) with a dry adult maintenance diet (control diet) or the therapeutic diet (u/d diet or S/O diet). Each treatment had a duration of 2-5 days, with 2- to 4-day washout periods in between. Urinary pH measurements were performed every 2 h between 07h00 and 15h00, with the food being given at 07h00 and 15h00, right after urine collection. The pH measurements obtained in each of the four treatments were compared to control (same dogs fed the control diet exclusively).
When compared to the control diet at the same time points, biologically relevant changes in urinary pH (defined as ≥0.5) were: increase with potassium citrate at 7h00 and 13h00; increase with u/d diet at 9h00, 13h00, and 15h00; decrease with S/O diet at 9h00 and 11h00; Urical did not have a detectable effect on urinary pH.
The present study confirms that therapeutic foods S/O and u/d, and potassium citrate supplement affected acid-base balance in healthy adult male beagle dogs, with the tested diets being more effective than the administered doses of the tested supplements at influencing urinary pH.
通过治疗性食物或补充剂来调节尿液 pH 值是治疗尿路结石的一部分。应研究这些饮食和补充剂的有效性，以确定哪种策略最有效。
假设/目的：评估口服补充柠檬酸钾、氯化铵溶液（Urical）和两种干治疗性食物——希尔处方饮食® u/d® 犬（u/d 饮食）和皇家宠物食品® 泌尿 S/O 犬（S/O 饮食）对犬在 8 小时内不同时间点的尿液 pH 值的影响。
7 只健康成年雄性研究比格犬。
一项为期 31 天的前瞻性干预研究。这些狗要么接受补充剂（柠檬酸钾或 rical）与干成年维持饮食（对照饮食）或治疗性饮食（u/d 饮食或 S/O 饮食）。每种治疗方法持续 2-5 天，中间有 2-4 天的洗脱期。在 07 点至 15 点之间每 2 小时进行一次尿液 pH 值测量，在 07 点和 15 点给食物，正好在尿液收集后。与仅喂食对照饮食的同一组狗（对照）相比，比较了 4 种治疗方法中获得的尿液 pH 值。
与对照饮食相比，在相同的时间点，尿液 pH 值发生了生物学相关的变化（定义为≥0.5）：柠檬酸钾在 7 点和 13 点增加；u/d 饮食在 9 点、13 点和 15 点增加；S/O 饮食在 9 点和 11 点减少；Urical 对尿液 pH 值没有明显影响。
本研究证实，治疗性食物 S/O 和 u/d 以及柠檬酸钾补充剂影响健康成年雄性比格犬的酸碱平衡，与所测试的补充剂相比，测试的饮食在影响尿液 pH 值方面更有效。
