Carra Rafael Bernhart, da Costa Capato Tamine Teixeira, Menezes Janaina Reis, Barbosa Egberto Reis, Duarte Kleber Paiva, Teixeira Manoel Jacobsen, Cury Rubens Gisbert
Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Functional Neurosurgery Division, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Clin Park Relat Disord. 2023 Oct 6;9:100220. doi: 10.1016/j.prdoa.2023.100220. eCollection 2023.
•Chronic spinal cord stimulation effectiveness was evaluated in four PD patients.•Double blinded cross over evaluation was performed using subthreshold stimulation.•An open label evaluation with regular suprathreshold stimulation was also performed.•No statistically significant effect was produced with either stimulation.•This study highlights the lack of strong clinical evidence supporting SCS for PD.
•对4名帕金森病患者评估了慢性脊髓刺激的有效性。
•使用阈下刺激进行双盲交叉评估。
•还进行了常规阈上刺激的开放标签评估。
•两种刺激均未产生统计学上的显著效果。
•本研究突出了缺乏有力临床证据支持脊髓刺激用于帕金森病治疗的情况。
