阿根廷人群中视神经脊髓炎谱系障碍患者的死亡率：来自RelevarEM注册研究。
Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry.
作者信息
Carnero Contentti Edgar, Lopez Pablo A, Pettinicchi Juan Pablo, Criniti Juan, Pappolla Agustín, Miguez Jimena, Cristiano Edgardo, Patrucco Liliana, Liwacki Susana, Tkachuk Verónica, Balbuena María E, Vrech Carlos, Deri Norma, Correale Jorge, Marrodan Mariano, Ysrraelit María C, Leguizamon Felisa, Luetic Geraldine, Menichini María L, Tavolini Darío, Mainella Carolina, Zanga Gisela, Burgos Marcos, Hryb Javier, Barboza Andrés, Lazaro Luciana, Alonso Ricardo, Fernández Liguori Nora, Nadur Débora, Alonso Serena Marina, Caride Alejandro, Paul Friedemann, Rojas Juan I
机构信息
Neuroimmunology Unit, Department of Neurosciences, Hospital Alemán, Buenos Aires, Argentina.
Servicio de Neurología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
出版信息
Mult Scler J Exp Transl Clin. 2023 Oct 17;9(4):20552173231205444. doi: 10.1177/20552173231205444. eCollection 2023 Oct-Dec.
We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75-2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, = 0.002) and higher disability score (HR = 2.30, < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients.
我们旨在评估阿根廷视神经脊髓炎谱系障碍（NMOSD）患者的死亡率和死亡原因，并确定死亡的预测因素。回顾性研究纳入了158例NMOSD患者，11例（7%）患者在11年的随访后死亡，总暴露时间为53345天，总体发病密度为2.06×10000患者/天（95%CI 1.75-2.68）。伴有呼吸衰竭的广泛性颈髓炎（45%）是最常见的死亡原因。发病时年龄较大（HR = 2.05，P = 0.002）和残疾评分较高（HR = 2.30，P < 0.001）是死亡的独立预测因素。我们发现阿根廷NMOSD患者的11年死亡率为7%。
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