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一项评估口腔白斑病和口腔鳞状细胞癌患者血清IgA和唾液IgA水平的研究。

A study to estimate the serum IgA and salivary IgA levels in patients with oral leukoplakia and oral squamous cell carcinoma.

作者信息

Yadav Parul, Shetty Vishwaprakash, Dave Aparna, Chandolia Betina, Mathur Apoorva, Saluja Pulin

机构信息

Department of Oral Pathology, Daswani Dental College, Kota, Rajasthan, India.

Department of Oral Pathology, Lenora Institute of Dental Sciences, Rajahumundry, AP, India.

出版信息

J Oral Maxillofac Pathol. 2023 Apr-Jun;27(2):275-281. doi: 10.4103/jomfp.jomfp_97_21. Epub 2023 Jul 13.

DOI:10.4103/jomfp.jomfp_97_21
PMID:37854900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10581321/
Abstract

CONTEXT

The increasing death rate because of oral cancer is mainly due to its late diagnosis. Tumour markers are often detected in abnormal amounts in blood, urine or saliva of patients with certain types of cancer. Diagnosing cancer through human saliva has advantages such as low invasiveness, minimum cost and easy sample collection. We have used serum immunoglobulin A (IgA) and salivary IgA for our present study.

AIMS

The aim of present study was to estimate serum and salivary IgA levels in oral leukoplakia and oral squamous cell carcinoma (OSCC) patients.

SETTINGS AND DESIGN

The study included 40 patients; 10 in the control group, 15 cases with oral leukoplakia and 15 cases with OSCC.

METHODS AND MATERIAL

The blood samples and saliva were taken from clinically diagnosed oral leukoplakia and OSCC patients and were tested for IgA levels.

STATISTICAL ANALYSIS USED

The data were analysed using SPSS 16.0. The mean values were compared between the groups by using analysis of variance (ANOVA) followed by post-hoc test for group-wise comparison. value ≤ 0.05 was considered significant.

RESULTS

It was observed that the comparison of levels of serum IgA in control and leukoplakia group; control and OSCC group; leukoplakia and OSCC group were found to be statistically significant. Also, comparison between the levels of salivary IgA in control and OSCC group was found to be statistically significant.

CONCLUSION

It is suggested that the serum and salivary IgA levels could be a better adjuvant diagnostic marker along with routine markers in patients with premalignant and malignant lesions.

摘要

背景

口腔癌死亡率上升主要归因于其诊断较晚。肿瘤标志物在某些类型癌症患者的血液、尿液或唾液中常呈现异常含量。通过人体唾液诊断癌症具有侵入性低、成本最低且样本采集容易等优点。本研究采用了血清免疫球蛋白A（IgA）和唾液IgA。

目的

本研究旨在评估口腔白斑和口腔鳞状细胞癌（OSCC）患者的血清和唾液IgA水平。

设置与设计

该研究纳入40名患者；对照组10名，口腔白斑患者15例，OSCC患者15例。

方法与材料

从临床诊断的口腔白斑和OSCC患者采集血液样本和唾液，并检测IgA水平。

所用统计分析方法

使用SPSS 16.0对数据进行分析。通过方差分析（ANOVA）比较各组均值，随后进行事后检验以进行组间比较。P值≤0.05被认为具有统计学意义。

结果

观察发现，对照组与白斑组、对照组与OSCC组、白斑组与OSCC组之间血清IgA水平的比较具有统计学意义。此外，对照组与OSCC组唾液IgA水平的比较也具有统计学意义。

结论

建议血清和唾液IgA水平可作为癌前和恶性病变患者常规标志物之外更好的辅助诊断标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/b6bc9c1d350a/JOMFP-27-275-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/fe75c1726509/JOMFP-27-275-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/60d21cd73e04/JOMFP-27-275-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/91377ab9d3cd/JOMFP-27-275-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/ad8deabfb379/JOMFP-27-275-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/c053e6d9459f/JOMFP-27-275-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/044efc675638/JOMFP-27-275-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/5e92388afa7e/JOMFP-27-275-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/8292aa11df9c/JOMFP-27-275-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/c6d25c9ada12/JOMFP-27-275-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/b6bc9c1d350a/JOMFP-27-275-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/fe75c1726509/JOMFP-27-275-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/60d21cd73e04/JOMFP-27-275-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/91377ab9d3cd/JOMFP-27-275-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/ad8deabfb379/JOMFP-27-275-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/c053e6d9459f/JOMFP-27-275-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/044efc675638/JOMFP-27-275-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/5e92388afa7e/JOMFP-27-275-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/8292aa11df9c/JOMFP-27-275-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/c6d25c9ada12/JOMFP-27-275-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/10581321/b6bc9c1d350a/JOMFP-27-275-g010.jpg

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