Rai Shalu, Mody R N
Department of Oral Medicine and Radiology, Institute of Dental Studies and Technologies, Modinagar, UP, India.
J Cancer Res Ther. 2012 Jan;8 Suppl 1:S116-22. doi: 10.4103/0973-1482.92225.
The aim of the study has been to quantitatively estimate and compare the circulating immune complexes (CIC) in pre-malignant and malignant lesions of oral cavity and to serially monitor the CIC levels in oral squamous cell carcinoma (SCC) during / following radiotherapy as to assess the status of the disease and to understand the prognostic significance.
The present study was carried out on 90 individuals divided into three groups and CIC was estimated by spectrophotometric method using polyethylene glycol (PEG) precipitation method. The mean CIC level was determined in each group and was correlated with the degree of differentiation and degree of dysplasia in malignant and pre-malignant group respectively. The effect of radiotherapy on the level of CIC was studied after 2400 rad and after one week of 4500 - 5000 rad.
It was observed that the mean CIC level in the control group was significantly lower (59.56 ± 8.11) when compared with the pre-malignant group (75.93 ± 12.89) and malignant group (92.66 ± 13.96). Among the pre-malignant group, leukoplakia had the highest mean CIC level followed by lichen planus and oral submucous fibrosis (OSMF), suggesting its greater malignant potential. No correlation could be established between degree of differentiation and degree of dysplasia with the CIC levels in malignant and premalignant groups respectively. There was a definite decrease in the mean CIC levels in patients undergoing radiotherapy.
The pretreatment value of CIC can be used as a prognostic indicator. A high CIC level would probably indicate a poor prognosis.
本研究旨在定量评估和比较口腔癌前病变与恶性病变中的循环免疫复合物（CIC），并在口腔鳞状细胞癌（SCC）放疗期间及放疗后连续监测CIC水平，以评估疾病状态并了解其预后意义。
本研究对90名个体进行，分为三组，采用聚乙二醇（PEG）沉淀法通过分光光度法评估CIC。测定每组的平均CIC水平，并分别与恶性组和癌前组的分化程度和发育异常程度相关联。在2400拉德放疗后以及4500 - 5000拉德放疗一周后研究放疗对CIC水平的影响。
观察到，与癌前组（75.93±12.89）和恶性组（92.66±13.96）相比，对照组的平均CIC水平显著较低（59.56±8.11）。在癌前组中，白斑的平均CIC水平最高，其次是扁平苔藓和口腔黏膜下纤维化（OSMF），表明其具有更大的恶性潜能。恶性组和癌前组的分化程度和发育异常程度与CIC水平之间均未建立相关性。接受放疗的患者平均CIC水平有明显下降。
CIC的预处理值可作为预后指标。高CIC水平可能表明预后不良。
