Nelson L R, Lewis J W, Kokka N, Branch B J, Taylor A N
Neurobehav Toxicol Teratol. 1986 Sep-Oct;8(5):469-74.
We have shown that adult rats, exposed to ethanol in utero, are hypersensitive to the analgesic and pituitary-adrenal activating effects of morphine. In the present experiment, two other responses to morphine, hyperthermia and hypothermia, were examined. Compared to controls, adult rats prenatally exposed to ethanol showed a potentiated hypothermic response to 10 and 30 mg/kg morphine. Hyperthermia elicited by low doses of morphine (1.25-5.0 mg/kg) was not affected by prenatal exposure to ethanol. These results extend our observations suggesting that exposure to ethanol in utero produces long-lasting perturbations in opioid systems. That hyperthermia is not affected, however, indicates that these changes are apparently not ubiquitous.
我们已经表明，子宫内接触乙醇的成年大鼠对吗啡的镇痛作用和垂体-肾上腺激活作用高度敏感。在本实验中，研究了对吗啡的另外两种反应，即体温过高和体温过低。与对照组相比，产前接触乙醇的成年大鼠对10毫克/千克和30毫克/千克吗啡表现出增强的体温过低反应。低剂量吗啡（1.25 - 5.0毫克/千克）引起的体温过高不受产前接触乙醇的影响。这些结果扩展了我们的观察结果，表明子宫内接触乙醇会对阿片系统产生持久的干扰。然而，体温过高未受影响表明这些变化显然并非普遍存在。
