Tavares M A, Paula-Barbosa M M, Cadete-Leite A
Neurobehav Toxicol Teratol. 1986 Sep-Oct;8(5):481-5.
The morphological effects of long-term alcohol consumption on the climbing fiber terminals of the cerebellum of adult rats were studied in groups of controls and animals fed a 20% aqueous alcohol solution for 1, 3, 6, 12, and 18 months. Following 12 months of alcohol consumption, vacated postsynaptic sites on Purkinje cell spines from large dendrites (the usual postsynaptic targets for climbing fiber terminals) were seen. Concomitantly, an increased number of climbing fiber profiles were observed in the inner third of the molecular layer. Their volumetric density (Vv) was significantly increased in 12 and 18-month alcohol-fed groups. Along with these findings, large numbers of climbing fiber terminals were seen in the outer third of the molecular layer, synapsing with Purkinje cell spines. The data show that climbing fiber terminals under these experimental conditions display structural plastic capabilities which presumably result in functional modifications on the cerebellar circuitry.
在对照组和喂食20%乙醇水溶液1、3、6、12和18个月的成年大鼠组中，研究了长期饮酒对成年大鼠小脑攀缘纤维终末的形态学影响。饮酒12个月后，在来自大的树突（攀缘纤维终末通常的突触后靶点）的浦肯野细胞棘上可见突触后位点空缺。与此同时，在分子层内三分之一处观察到攀缘纤维轮廓数量增加。在喂食乙醇12个月和18个月的组中，它们的体积密度（Vv）显著增加。伴随着这些发现，在分子层外三分之一处可见大量攀缘纤维终末与浦肯野细胞棘形成突触。数据表明，在这些实验条件下，攀缘纤维终末表现出结构可塑性，这可能导致小脑环路的功能改变。
