Mohammad F K, St Omer V E
Neurobehav Toxicol Teratol. 1986 Sep-Oct;8(5):551-60.
Groups (G) of pregnant rats were gavaged with 1:1, 2,4-D/2, 4, 5-T mixture at 0 (GO), 50 (G50), 100 (G100) and 125 (G125) mg/day on gestational days 6 to 15. G100 and G125 dams gained significantly less weight during pregnancy and delivered fewer offspring than control. Gestational lengths, neonatal sex ratios, birth weights, and physical appearance at birth were unaffected by treatments. On postnatal day (PND) 1, G125 mortality was significantly increased. Except for a significant weight reduction in G125 on PND60, postnatal growth and maturation were unaffected by treatments. 2,4-D/2, 4, 5-T significantly delayed male and female surface righting (PND2-5), and negative geotaxis at 45 degrees angle (PND15-17) in all groups; olfactory discrimination (PND9-11), and negative geotaxis at 25 degrees (PND7-11) in G100 and G125. On PND9 negative geotaxis at 25 degrees were significantly delayed in G50 females. d-Amphetamine challenges significantly increased running wheel activity of G125 males on PND22 and 23. 2,4-D/2,4,5-T was behaviorally teratogenic at all dosage levels.
在妊娠第6至15天，给怀孕大鼠组（G）灌胃1:1的2,4 - 二氯苯氧乙酸/2,4,5 - 三氯苯氧乙酸混合物，剂量分别为0（G0）、50（G50）、100（G100）和125（G125）毫克/天。与对照组相比，G100和G125组的母鼠在怀孕期间体重增加明显较少，产仔数也较少。妊娠时长、新生仔鼠性别比、出生体重和出生时的外观均不受处理影响。出生后第1天（PND1），G125组的死亡率显著增加。除了G125组在PND60时体重显著减轻外，产后生长和成熟不受处理影响。2,4 - 二氯苯氧乙酸/2,4,5 - 三氯苯氧乙酸显著延迟了所有组雄性和雌性的表面翻正反射（PND2 - 5），以及45度角的负趋地性（PND15 - 17）；G100和G125组的嗅觉辨别能力（PND9 - 11）以及25度角的负趋地性（PND7 - 11）也受到影响。在PND9时，G50组雌性的25度角负趋地性显著延迟。右旋苯丙胺激发试验显著增加了G125组雄性在PND22和23时的转轮活动。2,4 - 二氯苯氧乙酸/2,4,5 - 三氯苯氧乙酸在所有剂量水平下均具有行为致畸性。
