Torello L B, Yates A J, Hart R, Leon K S
Neurobiol Aging. 1986 Sep-Oct;7(5):337-46. doi: 10.1016/0197-4580(86)90160-0.
The lipids of aging brain were studied using a comparative-evolutionary model involving two species of mice, Mus Musculus (Mus) and Peromyscus leucopus (Peromyscus). Mus ages 2.5 times faster than does Peromyscus. Brain weight, water content, cholesterol, and ethanolamine plasmalogen decreased and phosphatidyl ethanolamine increased in both species with age. Differences between species included 12% more cholesterol/g total lipid extract in Peromyscus than in Mus throughout life, a linear increase with age in lipid phosphorus/g fresh weight at a faster rate in Peromyscus over Mus, and a linear increase in the total lipid extract weight throughout life in Mus but a decrease in Peromyscus. Cerebroside, sulfatide and GM1 ganglioside all increased during maturation and then decreased in old age in both mice. Lipid-bound sialic acid (ganglioside) increased linearly throughout life in Peromyscus but decreased slightly in Mus. These changes are interpreted to mean that the cellular membranes of Peromyscus may be inherently more stable than those of Mus, Peromyscus is better able to preserve its neuronal cell population with age than is Mus, proliferation of non-myelin membranes may occur in both species in advanced age, and both species of mice may experience some loss of myelin with age.
利用一种比较进化模型，对两种小鼠（小家鼠和白足鼠）的衰老大脑脂质进行了研究。小家鼠的衰老速度比白足鼠快2.5倍。随着年龄增长，两种小鼠的脑重量、含水量、胆固醇和乙醇胺缩醛磷脂均下降，磷脂酰乙醇胺增加。物种间的差异包括：在整个生命周期中，白足鼠每克总脂质提取物中的胆固醇比小家鼠多12%；白足鼠每克鲜重中脂质磷随年龄的线性增加速度比小家鼠快；小家鼠的总脂质提取物重量在整个生命周期中呈线性增加，而白足鼠则下降。在两种小鼠中，脑苷脂、硫脂和GM1神经节苷脂在成熟过程中均增加，然后在老年时下降。脂质结合唾液酸（神经节苷脂）在白足鼠的整个生命周期中呈线性增加，而在小家鼠中略有下降。这些变化被解释为意味着白足鼠的细胞膜可能比小家鼠的细胞膜具有更高的固有稳定性，随着年龄增长，白足鼠比小家鼠更能维持其神经元细胞群体，在老年时两种小鼠的非髓鞘膜可能都会发生增殖，并且两种小鼠可能都会随着年龄增长出现一些髓鞘损失。
