Hu Yaqi, Zhang Yifan, Wang Shuwen, Wang Rui, Yuan Qi, Zhu Leiqi, Xia Fangqi, Xue Mengzhen, Wang Yaqi, Li Yuanyang, Yuan Chengfu
Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China.
College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.
Curr Med Chem. 2025;32(4):678-687. doi: 10.2174/0109298673248494231010044348.
Long intergenic noncoding RNAs (lincRNAs) have a variety of properties that differ from those of messenger RNAs (mRNAs) encoding proteins. Long intergenic nonprotein coding RNA 667 (LINC00667) is a non-coding transcript located on chromosome 18p11.31. Recently, many studies have found that LINC00667 can enhance the progression of various cancers and play a key part in a lot of diseases, such as tumorigenesis. Therefore, LINC00667 can be recognized as a potential biomarker and therapeutic target. So, we reviewed the biological functions, relevant mechanisms, as well as clinical significance of LINC00667 in several human cancers in detail.
长链基因间非编码RNA（lincRNA）具有多种与编码蛋白质的信使RNA（mRNA）不同的特性。长链基因间非编码RNA 667（LINC00667）是一种位于18号染色体p11.31上的非编码转录本。最近，许多研究发现LINC00667可促进各种癌症的进展，并在许多疾病（如肿瘤发生）中起关键作用。因此，LINC00667可被视为一种潜在的生物标志物和治疗靶点。所以，我们详细综述了LINC00667在几种人类癌症中的生物学功能、相关机制以及临床意义。
