通过光敏化在水介质中获得的高量子产率超小LnO（Ln = Eu、Tb或Dy）纳米颗粒胶体

High-Quantum-Yield Ultrasmall LnO (Ln = Eu, Tb, or Dy) Nanoparticle Colloids in Aqueous Media Obtained via Photosensitization.

作者信息

Tegafaw Tirusew, Liu Ying, Ho Son Long, Liu Shuwen, Ahmad Mohammad Yaseen, Al Saidi Abdullah Khamis Ali, Zhao Dejun, Ahn Dabin, Nam Hyunji, Chae Weon-Sik, Nam Sung-Wook, Chang Yongmin, Lee Gang Ho

机构信息

Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.

Division of Biomedical Science, School of Medicine, Kyungpook National University, Taegu 41944, South Korea.

出版信息

Langmuir. 2023 Oct 31;39(43):15338-15342. doi: 10.1021/acs.langmuir.3c02229. Epub 2023 Oct 19.

DOI:10.1021/acs.langmuir.3c02229

Abstract

Fluorescent nanoparticles used in biomedical applications should be stable in their colloidal form in aqueous media and possess a high quantum yield (QY). We report ultrasmall LnO (Ln = Eu, Tb, or Dy) nanoparticle colloids with high QYs in aqueous media. The nanoparticles are grafted with hydrophilic and biocompatible poly(acrylic acid) (PAA) to ensure colloidal stability and biocompatibility and with organic photosensitizer 2,6-pyridinedicarboxylic acid (PDA) for achieving a high QY. The PAA/PDA-LnO nanoparticle colloids were nearly monodispersed and ultrasmall (particle diameter: ∼2 nm). They exhibited excellent colloidal stability with no precipitation after synthesis (>1.5 years) in aqueous media, very low cellular toxicity, and very high absolute QYs of 87.6, 73.6, and 2.8% for Ln = Eu, Tb, and Dy, respectively. These QYs are the highest reported so far for lanthanides in aqueous media. Therefore, the results suggest their high potential as sensitive optical or imaging probes in biomedical applications.

摘要

用于生物医学应用的荧光纳米颗粒在水性介质中应以胶体形式保持稳定，并具有高量子产率（QY）。我们报道了在水性介质中具有高量子产率的超小LnO（Ln = Eu、Tb或Dy）纳米颗粒胶体。这些纳米颗粒接枝了亲水性和生物相容性的聚（丙烯酸）（PAA）以确保胶体稳定性和生物相容性，并接枝了有机光敏剂2,6-吡啶二甲酸（PDA）以实现高量子产率。PAA/PDA-LnO纳米颗粒胶体几乎是单分散的且超小（粒径：约2 nm）。它们在水性介质中合成后（>1.5年）表现出优异的胶体稳定性，无沉淀，细胞毒性极低，对于Ln = Eu、Tb和Dy，其绝对量子产率分别高达87.6%、73.6%和2.8%。这些量子产率是迄今为止报道的镧系元素在水性介质中的最高值。因此，结果表明它们在生物医学应用中作为灵敏的光学或成像探针具有很高的潜力。

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