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识别、研究和控制耳念珠菌的工具和技术。

Tools and techniques to identify, study, and control Candida auris.

机构信息

Department of Biology, Ball State University, Muncie, Indiana, United States of America.

Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.

出版信息

PLoS Pathog. 2023 Oct 19;19(10):e1011698. doi: 10.1371/journal.ppat.1011698. eCollection 2023 Oct.

Abstract

Candida auris, is an emerging fungal pathogen that can cause life-threatening infections in humans. Unlike many other Candida species that colonize the intestine, C. auris most efficiently colonizes the skin. Such colonization contaminates the patient's environment and can result in rapid nosocomial transmission. In addition, this transmission can lead to outbreaks of systemic infections that have mortality rates between 40% and 60%. C. auris isolates resistant to all known classes of antifungals have been identified and as such, understanding the underlying biochemical mechanisms of how skin colonization initiates and progresses is critical to developing better therapeutic options. With this review, we briefly summarize what is known about horizontal transmission and current tools used to identify, understand, and control C. auris infections.

摘要

耳念珠菌是一种新兴的真菌病原体,可导致人类致命的感染。与许多定植于肠道的其他念珠菌属物种不同,耳念珠菌最有效地定植于皮肤。这种定植会污染患者的环境,并可能导致医院内的快速传播。此外,这种传播可能导致系统性感染的爆发,死亡率在 40%至 60%之间。已经鉴定出对所有已知类别的抗真菌药物均具有耐药性的耳念珠菌分离株,因此,了解皮肤定植如何开始和进展的潜在生化机制对于开发更好的治疗选择至关重要。通过这篇综述,我们简要总结了关于水平传播的已知内容以及目前用于识别、理解和控制耳念珠菌感染的工具。

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