原发性皮肤γδ T 细胞淋巴瘤伴异常 B 细胞标记物表达：一例罕见病例报告。
A Rare Case of Primary Cutaneous Gamma-Delta T-cell Lymphoma with Aberrant B-cell Marker Expression.
机构信息
Dermatopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
出版信息
Am J Dermatopathol. 2023 Nov 1;45(11):768-772. doi: 10.1097/DAD.0000000000002557.
Primary cutaneous gamma-delta T-cell lymphoma (PCGDTL) is a rare and diagnostically challenging primary skin lymphoma. We present a case of a 78-year-old otherwise healthy man who developed nonhealing nodules on his right posterior calf. Initial biopsy showed a dense, atypical, lymphoid infiltrate with gamma-delta and cytotoxic T-cell immunophenotypes. The diagnosis of PCGDTL was rendered; however, concurrent flow cytometry revealed expression of aberrant B-cell markers, including CD19 and cytoplasmic CD79a. Subsequent immunohistochemical studies corroborated this result. We report the extremely rare phenomenon of aberrant B-cell marker expression in PCGDTL, the first formally reported case to our knowledge.
原发性皮肤γδ T 细胞淋巴瘤（PCGDTL）是一种罕见且具有诊断挑战性的原发性皮肤淋巴瘤。我们报告了一例 78 岁的健康男性，他的右小腿后侧出现了无法愈合的结节。初次活检显示存在密集、异型的淋巴样浸润，具有γδ 和细胞毒性 T 细胞免疫表型。诊断为 PCGDTL；然而，同时进行的流式细胞术显示存在异常 B 细胞标志物的表达，包括 CD19 和细胞质 CD79a。随后的免疫组织化学研究证实了这一结果。我们报告了 PCGDTL 中异常 B 细胞标志物表达的极其罕见现象，据我们所知，这是首例正式报道的病例。
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