Department of Pathology, Cancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC) and Centro Hospitalar Universitário S. João, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.
Department of Pathology, Clínic Barcelona, Department of Basic Clinical Practice, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
Virchows Arch. 2024 Mar;484(3):401-422. doi: 10.1007/s00428-023-03658-8. Epub 2023 Oct 19.
Hydatidiform moles are rare and thus most pathologists and geneticists have little experience with their diagnosis. It is important to promptly and correctly identify hydatidiform moles given that they are premalignant disorders associated with a risk of persistent gestational trophoblastic disease and gestational trophoblastic neoplasia. Improvement in diagnosis can be achieved with uniformization of diagnostic criteria and establishment of algorithms. To this aim, the Pathology and Genetics Working Party of the European Organisation for Treatment of Trophoblastic Diseases has developed guidelines that describe the pathological criteria and ancillary techniques that can be used in the differential diagnosis of hydatidiform moles. These guidelines are based on the best available evidence in the literature, professional experience and consensus of the experts' group involved in its development.
葡萄胎较为罕见，因此大多数病理学家和遗传学家在诊断方面经验有限。鉴于葡萄胎是一种与持续性妊娠滋养细胞疾病和妊娠滋养细胞肿瘤风险相关的癌前病变，及时正确地识别葡萄胎至关重要。通过统一诊断标准和建立算法，可以提高诊断水平。为此，欧洲滋养细胞疾病治疗组织的病理学和遗传学工作组制定了指南，描述了在葡萄胎的鉴别诊断中可以使用的病理标准和辅助技术。这些指南基于文献中的最佳现有证据、专业经验以及参与指南制定的专家组的共识。
