Radostina A I
Ontogenez. 1986 Sep-Oct;17(5):508-15.
The effects of hydrocortisone and acetate deoxycorticosterone on the composition of the fibroblast population and the changes in their ultrastructure during the derma development in ontogenesis were studied using the electron morphometry. Hydrocortisone was shown to decrease in the derma of young animals the number of fibroblasts, which actively produce collagen, and to increase the number of fibrocytes and degenerating cells. Hydrocortisone reduced both in young and adult animals the total extent of the rough endoplasmic reticulum membranes, the total area of the rough endoplasmic reticulum and Golgi complex cisternae at the fibroblast section, as well as the area of the cytoplasm. The introduction of acetate deoxycorticosterone increased insignificantly the number of fiblroblasts, which actively produce collagen, in the derma of 2 month old animals. Under its influence the ultrastructure of the fibroblasts changed reliably only at the later stages of ontogenesis. Both the corticosteroids changed the bulk ratios of various organelles in the fibroblast's cytoplasm.
利用电子形态计量学研究了氢化可的松和醋酸脱氧皮质酮对个体发育过程中皮肤发育期间成纤维细胞群体组成及其超微结构变化的影响。结果表明，氢化可的松可减少幼龄动物皮肤中积极产生胶原蛋白的成纤维细胞数量，并增加纤维细胞和退化细胞的数量。氢化可的松还可减少幼龄和成年动物成纤维细胞切片中粗面内质网膜的总长度、粗面内质网和高尔基体池的总面积以及细胞质面积。注射醋酸脱氧皮质酮可使2月龄动物皮肤中积极产生胶原蛋白的成纤维细胞数量略有增加。在其影响下，成纤维细胞的超微结构仅在个体发育后期发生显著变化。两种皮质类固醇均改变了成纤维细胞细胞质中各种细胞器的体积比。
