Akhmerov R N
Ontogenez. 1986 Sep-Oct;17(5):516-24.
A marked increase in the rate of mitochondrial respiration, not coupled with ADP phosphorylation, was noted during the transformation of newborn poikilothermic animals into homoeothermic ones in the experiment on the rat tissue homogenates. Uncoupled respiration, as well as coupled one, is realized by the mitochondrial respiration chain, is observed upon oxidation of NADH, succinate, ascorbate and is expressed by a high rate of O2 consumption in the absence of added ADP. During ontogenesis, uncoupled respiration is activated to a greater extent in the heart and skeletal muscle and to a lesser extent in the liver and brown fat. The rates of phosphorylating oxidation of different substrates in tissue homogenates of animals from various age groups differ insignificantly. It is supposed that the postnatal development of homoeothermism in rats is ensured by the formation in many tissues of a system of uncoupled respiration, which takes part in heat production without preliminary ATP synthesis.
在对大鼠组织匀浆进行的实验中，发现新生变温动物转变为恒温动物的过程中，线粒体呼吸速率显著增加，且与ADP磷酸化无关。解偶联呼吸以及偶联呼吸都是通过线粒体呼吸链实现的，在NADH、琥珀酸、抗坏血酸氧化时均可观察到，表现为在不添加ADP的情况下氧气消耗速率很高。在个体发育过程中，解偶联呼吸在心脏和骨骼肌中激活程度较大，在肝脏和棕色脂肪中激活程度较小。不同年龄组动物组织匀浆中不同底物的磷酸化氧化速率差异不显著。据推测，大鼠出生后恒温性的发育是由许多组织中解偶联呼吸系统的形成来保证的，该系统参与产热而无需预先合成ATP。
