Institute of Climate Adaptation and Marine Biotechnology (ICAMB), Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.
Higher Institution Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia; Centre for Chemical Biology, Universiti Sains Malaysia, Minden, 11900, Penang, Malaysia; Department of Aquaculture, Faculty of Fisheries, Kasetsart University, 10900, Bangkok, Thailand.
Fish Shellfish Immunol. 2023 Nov;142:109171. doi: 10.1016/j.fsi.2023.109171. Epub 2023 Oct 17.
Protein-protein interactions (PPIs) are essential for understanding cell physiology in normal and pathological conditions, as they might involve in all cellular processes. PPIs have been widely used to elucidate the pathobiology of human and plant diseases. Therefore, they can also be used to unveil the pathobiology of infectious diseases in shrimp, which is one of the high-risk factors influencing the success or failure of shrimp production. PPI network analysis, specifically host-pathogen PPI (HP-PPI), provides insights into the molecular interactions between the shrimp and pathogens. This review quantitatively analyzed the research trends within this field through bibliometric analysis using specific keywords, countries, authors, organizations, journals, and documents. This analysis has screened 206 records from the Scopus database for determining eligibility, resulting in 179 papers that were retrieved for bibliometric analysis. The analysis revealed that China and Thailand were the driving forces behind this specific field of research and frequently collaborated with the United States. Aquaculture and Diseases of Aquatic Organisms were the prominent sources for publications in this field. The main keywords identified included "white spot syndrome virus," "WSSV," and "shrimp." We discovered that studies on HP-PPI are currently quite scarce. As a result, we further discussed the significance of HP-PPI by highlighting various approaches that have been previously adopted. These findings not only emphasize the importance of HP-PPI but also pave the way for future researchers to explore the pathogenesis of infectious diseases in shrimp. By doing so, preventative measures and enhanced treatment strategies can be identified.
蛋白质-蛋白质相互作用 (PPIs) 对于理解正常和病理条件下的细胞生理学至关重要，因为它们可能涉及所有细胞过程。PPIs 已被广泛用于阐明人类和植物疾病的病理生物学。因此，它们也可用于揭示虾类传染病的病理生物学，这是影响虾类生产成败的高风险因素之一。蛋白质-蛋白质相互作用网络分析，特别是宿主-病原体蛋白质-蛋白质相互作用 (HP-PPI)，提供了对虾与病原体之间分子相互作用的深入了解。本综述通过使用特定关键字、国家、作者、组织、期刊和文献进行文献计量分析，定量分析了该领域的研究趋势。该分析从 Scopus 数据库中筛选了 206 条记录以确定其合格性，最终检索到 179 篇论文进行文献计量分析。分析表明，中国和泰国是该特定研究领域的推动力量，并且经常与美国合作。水产养殖和水生生物疾病是该领域出版物的主要来源。确定的主要关键词包括“白斑综合征病毒”、“WSSV”和“虾”。我们发现，目前关于 HP-PPI 的研究相当稀缺。因此，我们通过强调之前采用的各种方法，进一步讨论了 HP-PPI 的意义。这些发现不仅强调了 HP-PPI 的重要性，也为未来的研究人员探索虾类传染病的发病机制铺平了道路。通过这样做，可以确定预防措施和增强治疗策略。
