COVID-19 大流行对皮肤鳞状细胞癌的影响：一项单中心的流行病学、临床和组织病理学因素研究。
Impact of COVID-19 Pandemic on Cutaneous Squamous Cell Carcinoma: A Single-Centre Study of Epidemiologic, Clinic and Histopathological Factors.
机构信息
Dermatology Unit, Virgen de las Nieves University Hospital, Granada, Spain; TECe19-Investigational and Translational Dermatology Research Group, Instituto de Investigación Biosanitaria (IBS), Granada, Spain.
TECe19-Investigational and Translational Dermatology Research Group, Instituto de Investigación Biosanitaria (IBS), Granada, Spain; Department of Preventive Medicine and Public Health, School of Medicine, University of Granada, Granada, Spain.
出版信息
Actas Dermosifiliogr. 2024 Mar;115(3):224-230. doi: 10.1016/j.ad.2023.10.003. Epub 2023 Oct 17.
BACKGROUND
The COVID-19 pandemic may have adversely affected the early diagnosis of skin cancer.
OBJECTIVE
To compare epidemiological, clinical and histopathological characteristics in patients undergoing cutaneous squamous cell carcinoma (SCC) surgery before and after the beginning of the pandemic.
MATERIAL & METHODS: We conducted a cross-sectional study including two case series: (1) patients operated on for SCC in the year after the first state of alarm in Spain (15 March 2020), and (2) patients with SCC operated on in the previous year. Epidemiological, clinical and histopathological variables, tumour stage and risk grade were collected.
RESULTS
248 patients were included (127 undergoing surgery before the pandemic and 121 after the pandemic). After the beginning of the pandemic, the percentage of high-risk SCC significantly increased from 35.3% to 46.2% (p=0.011). However, no significant differences were found in thickness, perineural invasion or metastases.
CONCLUSIONS
Although there has not been a significant reduction in the number of SCC operated on after the pandemic, there has been a significant increase in high-risk SCC. All this could lead to an increase in skin cancer mortality in the future.
背景
COVID-19 大流行可能对皮肤癌的早期诊断产生了不利影响。
目的
比较大流行前后行皮肤鳞状细胞癌（SCC）手术患者的流行病学、临床和组织病理学特征。
材料与方法
我们进行了一项横断面研究，包括两个病例系列：（1）西班牙首次进入警戒状态后一年接受 SCC 手术的患者（2020 年 3 月 15 日），以及（2）前一年接受 SCC 手术的患者。收集了流行病学、临床和组织病理学变量、肿瘤分期和风险等级。
结果
共纳入 248 例患者（大流行前手术 127 例，大流行后手术 121 例）。大流行开始后，高危 SCC 的比例从 35.3%显著增加至 46.2%（p=0.011）。然而，厚度、神经周围侵犯或转移方面无显著差异。
结论
尽管大流行后接受 SCC 手术的数量没有显著减少，但高危 SCC 的比例显著增加。所有这些都可能导致未来皮肤癌死亡率的增加。
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