经Mohs 显微外科手术治疗的皮肤口腔周围和唇红部非黑素瘤皮肤癌的特征。
Characteristics of non-melanoma skin cancers of the cutaneous perioral and vermilion lip treated by Mohs micrographic surgery.
机构信息
Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA.
出版信息
J Eur Acad Dermatol Venereol. 2019 Feb;33(2):305-311. doi: 10.1111/jdv.15263. Epub 2018 Nov 6.
BACKGROUND
The lip and surrounding perioral region are susceptible to non-melanoma skin cancer, but the distribution of basal cell and squamous cell carcinoma on the cutaneous and vermilion lips has not been fully elucidated.
OBJECTIVE
To investigate the distribution of cutaneous and vermilion lip non-melanoma skin cancer and to better describe risk factors, anatomic location, treatment characteristics and oncologic outcomes.
METHODS
A retrospective comparative case series of patients undergoing Mohs micrographic surgery (MMS) at a single academic centre for lip and perioral basal cell and squamous cell carcinoma was performed over a 5-year period. Demographics, medical comorbidities, surgical characteristics and recurrence status were extracted.
RESULTS
Forty-five vermilion and 116 cutaneous lip cancers were identified. Basal cell carcinoma (BCC) was more common in the cutaneous perioral region, while squamous cell carcinoma (SCC) was more common on the vermilion lip (P < 0.001). BCCs were more common on the upper vermilion lip and SCCs were more common on the lower vermilion lip (P < 0.001). Within the cutaneous perioral region, both BCCs and SCCs were more common on the upper perioral surface (P = 0.002). Male gender was associated with lower lip SCC (P = 0.015). Smoking, immunosuppression, anticoagulant use and hydrochlorothiazide use were not associated with cancer type or location. Recurrences were rare, but more common in vermilion lip cancers (6.6%) compared to perioral cutaneous cancers (0.8%). Outcomes for all groups were similar; BCCs of the vermilion lip had significantly greater mean MMS stages (P < 0.001) as did SCCs (P = 0.05).
CONCLUSION
Basal cell carcinoma is more commonly encountered on the cutaneous lip, whereas SCC is more common on the vermilion lip. Within the vermilion lip, BCC favours the upper lip, while SCC favours the lower lip. Within the cutaneous perioral region, both BCC and SCC favour the upper cutaneous tissue. Early stage lip cancers are curable by Mohs micrographic surgery with rare recurrences.
背景
嘴唇及周围口周区域易发生非黑素瘤皮肤癌，但基底细胞癌和鳞状细胞癌在皮肤和唇红区的分布尚未完全阐明。
目的
探讨皮肤和唇红区非黑素瘤皮肤癌的分布，更好地描述其危险因素、解剖位置、治疗特征和肿瘤学结果。
方法
对单中心在过去 5 年期间行 Mohs 显微外科手术（MMS）治疗的唇部和口周皮肤基底细胞癌和鳞状细胞癌患者进行回顾性对比病例系列研究。提取人口统计学、合并症、手术特征和复发情况。
结果
共发现 45 例唇红区和 116 例皮肤唇癌。基底细胞癌（BCC）在皮肤口周区域更常见，而鳞状细胞癌（SCC）在唇红区更常见（P<0.001）。BCC 更常见于唇红上区，SCC 更常见于唇红下区（P<0.001）。在皮肤口周区域，BCC 和 SCC 在上口周表面更常见（P=0.002）。男性下唇 SCC 发生率较低（P=0.015）。吸烟、免疫抑制、抗凝药物和氢氯噻嗪的使用与癌症类型或位置无关。复发罕见，但唇红癌（6.6%）较口周皮肤癌（0.8%）更常见。所有组别的结果均相似；唇红 BCC 的 MMS 分期明显更高（P<0.001），SCC 也更高（P=0.05）。
结论
BCC 更常见于皮肤唇，而 SCC 更常见于唇红。在唇红区，BCC 更倾向于上唇，而 SCC 更倾向于下唇。在皮肤口周区域，BCC 和 SCC 都更倾向于上唇皮肤。早期唇癌可通过 Mohs 显微外科手术治愈，复发罕见。
Zotero 插件