利用接枝有FeO@GO的纳米复合气凝胶对呼出气冷凝物中的美托洛尔进行萃取和测定。

Utilizing a nanocomposite aerogel grafted with FeO@GO for the extraction and determination of metoprolol in exhaled breath condensate.

作者信息

Azad Bita, Karimzadeh Zahra, Jabbaripour Amirreza, Jouyban-Gharamaleki Vahid, Khoubnasabjafari Maryam, Jouyban Abolghasem, Rahimpour Elaheh

机构信息

Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences Tabriz Iran

Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences Tabriz Iran.

出版信息

RSC Adv. 2023 Oct 18;13(43):30562-30574. doi: 10.1039/d3ra03883a. eCollection 2023 Oct 11.

This article presents a solid-phase extraction method combined with a spectrofluorometric method for the extraction/pre-concentration and determination of metoprolol (MET) in exhaled breath condensate. The extraction sorbent is an agarose aerogel nanocomposite grafted with graphene oxide (GO) FeO. The size and morphology of the nanosorbent were characterized X-ray crystallography, scanning electron microscopy, Fourier-transform infrared spectrometry, and Brunauer-Emmett-Teller analysis. Factors affecting the extraction/determination of MET were optimized using the one-at-a-time method. Under optimized experimental conditions, the calibration graph was linear in the range of 0.005 to 2.0 μg mL with a detection limit of 0.001 μg mL. The method was successfully applied for the determination of MET in biological samples taken from patients receiving MET.