Zhao Yuan, Zhao Jing, Xie Ruijie, Zhang Yu, Xu Ya, Mao Jing, Yan Cheng, Sun Yi
Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Department of Gynecology, Hebei General Hospital, Shijiazhuang, China.
Front Oncol. 2023 Oct 4;13:1265356. doi: 10.3389/fonc.2023.1265356. eCollection 2023.
HPV infection is closely related to the occurrence of cervical cancer and has an important adverse effect on human life and health. This study used data from the NHANES 2003-2016 to investigate the relationship between PIR and HPV infection status among Americans aged 20 and older.
The data for this cross-sectional investigation came from the 2003-2016 National Health and Nutrition Examination Survey (NHANES), which included 9580 women who were 20 years of age or older. The linear and nonlinear correlations between PIR and the presence of HPV infection were investigated using multiple linear regression and smooth curve fitting. The stability of the relationship across groups was examined using subgroup analysis and interaction tests.
There were 2232 impoverished homes and 2543 rich households among the 9580 adult participants aged 20 and above. PIR (ratio of income to poverty) was found to be significantly inversely related to the presence of HPV infection [0.91 (0.89, 0.94)] after adjusting for all other covariates, and the trend persisted even after categorizing PIR into high- and low-income groups (PIR>4 and PIR<1). In addition, significant negative relationships were discovered in subgroup analyses for women aged 25 to 59 [0.90 (0.88, 0.93)], non-Hispanic whites [0.80 (0.70, 0.92)], non-diabetics [0.91 (0.88, 0.94)], and those who had ever engaged in sex [0.91 (0.89, 0.94)].
PIR was highly and negatively correlated with the presence of HPV infection in American women aged 20 and older. The results of this study are of great significance for preventing HPV infection and improving the accuracy of HPV screening.
人乳头瘤病毒（HPV）感染与宫颈癌的发生密切相关，对人类生命健康有重要不良影响。本研究使用2003 - 2016年美国国家健康与营养检查调查（NHANES）的数据，调查20岁及以上美国人的贫困收入比（PIR）与HPV感染状况之间的关系。
这项横断面调查的数据来自2003 - 2016年国家健康与营养检查调查（NHANES），其中包括9580名20岁及以上的女性。使用多元线性回归和平滑曲线拟合研究PIR与HPV感染存在之间的线性和非线性相关性。通过亚组分析和交互检验检查各群体间关系的稳定性。
在9580名20岁及以上的成年参与者中，有2232户贫困家庭和2543户富裕家庭。在调整所有其他协变量后，发现贫困收入比（收入与贫困之比）与HPV感染的存在显著负相关[0.91（0.89，0.94）]，即使将PIR分为高收入和低收入组（PIR>4和PIR<1）后，这种趋势仍然存在。此外，在25至59岁女性[0.90（0.88，0.93）]、非西班牙裔白人[0.80（0.70，0.92）]、非糖尿病患者[0.91（0.88，0.94）]以及有过性行为的人群[0.91（0.89，0.94）]的亚组分析中发现了显著的负相关关系。
贫困收入比与20岁及以上美国女性HPV感染的存在高度负相关。本研究结果对于预防HPV感染和提高HPV筛查的准确性具有重要意义。
