Chen Haiwei, Chen Xiaotong, Chen Yuling, Tang Lixin, Shi Wen-Jing, Ou Yu-Hua
Department of Clinical Medicine, The Second Clinical College of Guangzhou Medical University, Guangzhou, China.
Department of Gynecology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Front Nutr. 2025 May 30;12:1594489. doi: 10.3389/fnut.2025.1594489. eCollection 2025.
In the post-vaccine era, adjusting living habits and diet structure has become a new way to prevent Human papillomavirus(HPV). Although dietary factors have received much attention, the association of dietary magnesium with HPV infection remains understudied.
Using NHANES cross-sectional data from 2003 to 2016, this study analyzed the relationship between magnesium intake and HPV infection in 7,246 women aged 18-59 years. Weighted logistic regression and subgroup analysis assessed independent links, while curve fitting and threshold analysis defined dose response and saturation.
A significant negative correlation was observed between magnesium intake and the risk of HPV infection. After comprehensive adjustment for potential confounding factors, individuals in the highest quartile of magnesium intake exhibited a statistically significant 29.7% reduction in the risk of HPV infection for each additional unit, compared to those in the lowest quartile (CI:0.554-0.894, = 0.005). Besides, using smooth curve fitting and threshold analysis, we found an L-shaped dose response between magnesium intake and HPV risk. Below 401 mg/day of magnesium, increased intake is inversely correlated with HPV infection risk. Above this threshold, further increases plateaued in risk reduction.
Moderate magnesium intake has a protective effect against HPV infection. Rationally increasing magnesium intake through dietary channels is expected to serve as an effective preventive measure against HPV infection.
在疫苗接种后的时代，调整生活习惯和饮食结构已成为预防人乳头瘤病毒（HPV）的新途径。尽管饮食因素已受到广泛关注，但饮食中镁与HPV感染之间的关联仍未得到充分研究。
本研究利用2003年至2016年美国国家健康与营养检查调查（NHANES）的横断面数据，分析了7246名18至59岁女性的镁摄入量与HPV感染之间的关系。加权逻辑回归和亚组分析评估了独立关联，而曲线拟合和阈值分析则确定了剂量反应和饱和度。
观察到镁摄入量与HPV感染风险之间存在显著负相关。在对潜在混杂因素进行全面调整后，镁摄入量最高四分位数的个体每增加一个单位，与最低四分位数的个体相比，HPV感染风险在统计学上显著降低29.7%（CI：0.554 - 0.894，P = 0.005）。此外，通过平滑曲线拟合和阈值分析，我们发现镁摄入量与HPV风险之间呈L形剂量反应。镁摄入量低于401毫克/天时，摄入量增加与HPV感染风险呈负相关。高于此阈值，风险降低趋于平稳。
适度摄入镁对HPV感染具有保护作用。通过饮食途径合理增加镁摄入量有望成为预防HPV感染的有效措施。
