Wagner E
Chir Forum Exp Klin Forsch. 1978(1978):293-8.
The dose and time dependence of the immunosuppressive effect of prednisolone on renal allograft survival and antibody formation was studied in inbred rats. A single injection of 50 - 300 mg prednisolone/kg body wt. on the day of transplantation resulted in a dose-dependent prolongation of mean graft survival to 12.8 days as compared to 7.8 days for untreated controls. The daily postoperative administration of 10 and 30 mg prednisolone/kg prolonged the mean survival time to a lesser extent. A single bolus injection of 300 mg prednisolone/kg at different times after transplantatin resulted in a significant prolongation of graft survival and suppression of cytotoxic antibody only when given no later than 2 days postoperatively or following antigen injection.
在近交系大鼠中研究了泼尼松龙免疫抑制作用对肾移植存活及抗体形成的剂量和时间依赖性。移植当天单次注射50 - 300mg泼尼松龙/千克体重，与未治疗的对照组平均移植存活时间7.8天相比，移植存活时间呈剂量依赖性延长至12.8天。术后每日给予10mg和30mg泼尼松龙/千克体重，平均存活时间延长程度较小。移植后不同时间单次推注300mg泼尼松龙/千克体重，仅在术后2天内或抗原注射后给药时，才会显著延长移植存活时间并抑制细胞毒性抗体。
