Taks Esther J M, Moorlag Simone J C F M, Föhse Konstantin, Simonetti Elles, van der Gaast-de Jongh Christa E, van Werkhoven Cornelis H, Bonten Marc J M, Oever Jaap Ten, de Jonge Marien I, van de Wijgert Janneke H H M, Netea Mihai G
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
iScience. 2023 Sep 28;26(11):108062. doi: 10.1016/j.isci.2023.108062. eCollection 2023 Nov 17.
Earlier studies showed that BCG vaccination improves antibody responses of subsequent vaccinations. Similarly, in older volunteers we found an increased IgG receptor-binding domain (RBD) concentration after SARS-CoV-2 infection if they were recently vaccinated with BCG. This study aims to assess the effect of BCG on the serum antibody concentrations induced by COVID-19 vaccination in a population of adults older than 60 years. Serum was collected from 1,555 participants of the BCG-CORONA-ELDERLY trial a year after BCG or placebo, and we analyzed the anti-SARS-CoV-2 antibody concentrations using a fluorescent-microsphere-based multiplex immunoassay. Individuals who received the full primary COVID-19 vaccination series before serum collection and did not test positive for SARS-CoV-2 between inclusion and serum collection were included in analyses (n = 945). We found that BCG vaccination before first COVID-19 vaccine (median 347 days [IQR 329-359]) did not significantly impact the IgG RBD concentration after COVID-19 vaccination in an older European population.
早期研究表明，卡介苗接种可改善后续疫苗接种的抗体反应。同样，在老年志愿者中，我们发现，如果他们最近接种了卡介苗，那么在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后，其免疫球蛋白G（IgG）受体结合域（RBD）浓度会升高。本研究旨在评估卡介苗对60岁以上成年人中由2019冠状病毒病（COVID-19）疫苗诱导的血清抗体浓度的影响。在接种卡介苗或安慰剂一年后，从卡介苗-冠状病毒-老年人试验的1555名参与者中采集血清，我们使用基于荧光微球的多重免疫测定法分析了抗SARS-CoV-2抗体浓度。分析纳入了在血清采集前接受了完整的COVID-19初级疫苗接种系列且在纳入研究至血清采集期间SARS-CoV-2检测未呈阳性的个体（n = 945）。我们发现，在首次接种COVID-19疫苗前（中位数347天[四分位距329 - 359]）接种卡介苗，对老年欧洲人群接种COVID-19疫苗后的IgG RBD浓度没有显著影响。
