Variations in activation energy and nuclei size during nucleation explain chiral symmetry breaking.

We show that variations in enantiomer nuclei size and activation energy during the nucleation stage of crystallization are responsible for the chiral symmetry breaking resulting in excess of one of the possible enantiomers with respect to the other. By understanding the crystallisation process as a non-equilibrium self-assembly process, we quantify the enantiomeric excess through the probability distribution of the nuclei size and activation energy variations which are obtained from the free energy involved in the nucleation stage of crystallisation. We validate our theory by comparing it to Kondepudi previous experimental work on sodium chlorate crystallisation. The results demonstrate that the self-assembly of enantiomeric crystals provides an explanation for chiral symmetry breaking. These findings could have practical applications for improving the production of enantiopure drugs in the pharmaceutical industry, as well as for enhancing our understanding of the origins of life since enantiomeric amino acids and monosaccharides are the building blocks of life.