School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China.
Curr Top Med Chem. 2023;23(28):2609-2620. doi: 10.2174/0115680266264515230921052521.
Bruton tyrosine kinase (BTK) is an important protein of the tyrosine kinase family and plays a key role in signal transduction, proliferation, migration, and survival in B lymphocytes. The inhibition of BTK is a promising therapy for various autoimmune diseases (AD) involving abnormal B cell function, such as rheumatoid arthritis (RA), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). This article briefly summarizes the role of BTK in the BCR signaling pathway, the development process of BTK inhibitors, and especially the latest progress of their clinical trials for the treatment of AD.
布鲁顿酪氨酸激酶（BTK）是酪氨酸激酶家族中的重要蛋白，在 B 淋巴细胞的信号转导、增殖、迁移和存活中发挥关键作用。BTK 的抑制作用是治疗涉及异常 B 细胞功能的各种自身免疫性疾病（AD）的一种有前途的疗法，如类风湿关节炎（RA）、多发性硬化症（MS）和系统性红斑狼疮（SLE）。本文简要总结了 BTK 在 BCR 信号通路中的作用、BTK 抑制剂的研发过程，特别是其用于治疗 AD 的临床试验的最新进展。
