Department of Respiratory and Critical Care Medicine, Xiamen Humanity Hospital Fujian Medical University, Xiamen, Fujian, China.
Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Medicine (Baltimore). 2023 Oct 20;102(42):e35329. doi: 10.1097/MD.0000000000035329.
Diabetes mellitus (DM) plays a vital role in the development of cardiovascular disease. However, its association with venous thromboembolism (VTE) remains unclear, for the published study results are conflicting. We performed a meta-analysis of published cohort studies and case-control studies to assess the role of DM in the formation and prognosis of VTE.
PubMed and EMBASE databases were searched for articles from the database's establishment until September 15, 2022. Of the 15,754 publications retrieved, 50 studies were identified that met the selection criteria. The New castle-Ottawa Scale was used to evaluate the quality of the literature. Pooled odds ratios (ORs) and 95% confidence intervals were calculated using fixed- or random-effect models.
We combined OR using a random-effects or fixed-effects model: patients with DM had an increased risk of VTE (OR 1.27, 95% confidence interval [CI]: 1.15-1.41), which still showed a partial association in studies adjusted by confounding factors (OR 1.20, 95% CI: 1.07-1.35). DM was not significantly associated with VTE when analyzed in studies adjusted by body mass index (OR 1.04, 95% CI: 0.94-1.15). VTE patients with DM had a higher risk of short-term and long-term mortality than those without DM (OR 1.58 [95% CI: 1.26-1.99] for long-term mortality and OR 1.20 [95% CI: 1.19-1.21] for short-term mortality).
There was no significant association between DM and VTE risk, and body mass index may be a significant confounding factor between DM and VTE risk. However, DM can still lead to an increased risk of long-term and short-term mortality in patients with VTE.
糖尿病（DM）在心血管疾病的发展中起着至关重要的作用。然而，其与静脉血栓栓塞（VTE）的关系尚不清楚，因为已发表的研究结果存在冲突。我们对已发表的队列研究和病例对照研究进行了荟萃分析，以评估 DM 在 VTE 形成和预后中的作用。
检索了 PubMed 和 EMBASE 数据库，从数据库建立到 2022 年 9 月 15 日的文章。从检索到的 15754 篇文献中，确定了符合选择标准的 50 项研究。使用纽卡斯尔-渥太华量表评估文献质量。使用固定效应或随机效应模型计算合并的比值比（OR）和 95%置信区间。
我们使用随机效应或固定效应模型合并 OR：DM 患者发生 VTE 的风险增加（OR 1.27，95%置信区间[CI]：1.15-1.41），在调整混杂因素的研究中仍显示出部分相关性（OR 1.20，95% CI：1.07-1.35）。当分析调整 BMI 的研究时，DM 与 VTE 无显著相关性（OR 1.04，95% CI：0.94-1.15）。与无 DM 的 VTE 患者相比，DM 患者的短期和长期死亡率更高（长期死亡率的 OR 1.58 [95% CI：1.26-1.99]和短期死亡率的 OR 1.20 [95% CI：1.19-1.21]）。
DM 与 VTE 风险之间无显著相关性，BMI 可能是 DM 与 VTE 风险之间的重要混杂因素。然而，DM 仍可导致 VTE 患者的长期和短期死亡率增加。
