Leonardi S, Fischer A, Di Dio R, D'Agata A, Musumeci S
Pediatr Med Chir. 1986 Mar-Apr;8(2):189-200.
A retrospective study of 112 infants admitted at Pediatric Clinic of Catania from 1970 to 1985 with diagnosis of "Cholestatic jaundice" shows two prevalent pathologies: neonatal hepatitis and biliary atresia. Some other disease like cystic fibrosis. Hereditary fructose intolerance, Galactosaemia, Paucity of bile duct were found rarely. Some laboratory parameters (Serum direct bilirubin, Alkaline Phosphatase, Alkaline Phosphatase/Transaminase (GOT) show a characteristic pattern. Therefore the analysis of these data could help us to make a probability diagnosis and anticipate the liver biopsy that remain the most sensitive diagnostic instrument. In fact it is known that the earlier diagnosis is very important for the prognosis of these infants.
一项对1970年至1985年间在卡塔尼亚儿科诊所收治的112例诊断为“胆汁淤积性黄疸”的婴儿的回顾性研究显示，有两种主要病症：新生儿肝炎和胆道闭锁。其他一些疾病，如囊性纤维化、遗传性果糖不耐受、半乳糖血症、胆管稀少等则很少见。一些实验室参数（血清直接胆红素、碱性磷酸酶、碱性磷酸酶/转氨酶（谷草转氨酶））呈现出一种特征性模式。因此，对这些数据的分析有助于我们进行可能性诊断，并预判仍为最敏感诊断手段的肝活检。事实上，众所周知，早期诊断对这些婴儿的预后非常重要。
