Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Altai Branch of National Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Barnaul, Russia.
Bull Exp Biol Med. 2023 Sep;175(5):690-694. doi: 10.1007/s10517-023-05927-7. Epub 2023 Oct 20.
The effects of a lithium-modified sorbent based on aluminum oxide and polydimethylsiloxane (AlO@PDMS/Li) and a lithium-free sorbent (AlO@PDMS) on some indicators characterizing blood clotting under hemosorption conditions were compared in vitro. Sorbent AlO@PDMS/Li had significantly lower reactogenic effect on the blood passed through the column than the sorbent without lithium. This was seen from the degree of platelet reduction (66×10 vs 19×10/liter) as well as a less pronounced hypercoagulation shift in chronometric indicators. In contrast to lithium-free sorbent, AlO@PDMS/Li demonstrated the ability to reduce the concentration of fibrinogen. However, this had no impact on the density characteristics of the blood clot assessed by thromboelastometry such as maximum clot firmness, angle and fibrin clot formation time, amplitudes at 10 and 15 min after clotting time, which are known to depend on the quantity of platelets and the concentration of functionally active fibrinogen.
比较了基于氧化铝和聚二甲基硅氧烷的锂改性吸附剂（AlO@PDMS/Li）和无锂吸附剂（AlO@PDMS）在体外对血液吸附条件下一些凝血指标的影响。与不含锂的吸附剂相比，通过柱的血液的血小板减少程度（66×10 对 19×10/liter）以及计时指标中更不明显的高凝转移表明，吸附剂 AlO@PDMS/Li 对血液的反应性明显降低。与无锂吸附剂不同，AlO@PDMS/Li 表现出降低纤维蛋白原浓度的能力。然而，这对血栓弹性描记术评估的血液凝块的密度特征没有影响，例如最大凝块硬度、角和纤维蛋白凝块形成时间、凝血时间后 10 和 15 分钟的振幅，这些特征已知取决于血小板的数量和功能活性纤维蛋白原的浓度。
