Wernert N, Antalffy A, Dhom G
Pathol Res Pract. 1986 Oct;181(5):551-7. doi: 10.1016/S0344-0338(86)80148-0.
Eight-week-old male and female Sprague Dawley rats are treated with 10 micrograms estradiol daily i.p. for 2 and 4 weeks respectively. Under treatment pituitary and adrenal weight increases in males and similates to those of females. As a relative measure for the cell sizes in the different zones of the adrenal cortex the number of nuclei/constant area is determined. In the outer zona fasciculata estradiol leads to a feminization of cell pattern in males with increase of cell sizes and partly also development of a female liposome pattern. An increase of cell sizes in the zona reticularis between the second and fourth week of treatment is restricted to male animals. In the zona glomerulosa cell sizes increase in males between the 10th and 12th week of life, independent of estradiol. In both sexes estradiol causes a significant dilatation of sinusoids of adrenal medulla. Most of the findings can be explained by known biochemical aspects of corticosterone metabolism of the rat.
八周龄的雄性和雌性斯普拉格-道利大鼠分别腹腔注射每日10微克雌二醇，持续2周和4周。在治疗过程中，雄性大鼠的垂体和肾上腺重量增加，且与雌性大鼠相似。作为肾上腺皮质不同区域细胞大小的相对测量指标，测定单位面积内的细胞核数量。在束状带外层，雌二醇导致雄性大鼠细胞模式女性化，细胞大小增加，部分还出现了雌性脂质体模式。在治疗的第二至第四周，网状带细胞大小的增加仅限于雄性动物。在球状带，雄性大鼠在出生后第10至12周细胞大小增加，与雌二醇无关。在两性中，雌二醇都会导致肾上腺髓质血窦显著扩张。大多数研究结果可以用大鼠皮质酮代谢的已知生化方面来解释。
