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利用吲哚菁绿视频血管造影术填补低收入和中等收入国家颅内动脉瘤治疗差距:一篇综述。

Utilizing indocyanine green video angiography to bridge intracranial aneurysm treatment gaps in low- and middle-income countries: a mini-review.

作者信息

Ghosh Shankhaneel, Awuah Wireko Andrew, Bharadwaj Hareesha Rishab, Adebusoye Favour Tope, Ou Yong Brian M, Wellington Jack, Abdul-Rahman Toufik, Ovechkin Denys

机构信息

Institute of Medical Sciences and SUM Hospital, Bhubaneswar, India.

Sumy State University, Sumy, Ukraine.

出版信息

J Int Med Res. 2023 Oct;51(10):3000605231204427. doi: 10.1177/03000605231204427.

Abstract

Intracranial aneurysms, affecting 2%-5% of the population, pose a significant challenge to neurosurgeons due to their potential to cause subarachnoid haemorrhage and high mortality rates. Intraoperative angiography is necessary for effective surgical planning and indocyanine green video angiography (ICG-VA) has emerged as a useful tool for real-time visualization of aneurysmal blood flow, aiding in better planning for potential blood flow and detection of aneurysm remnants. This mini narrative review explores the application of ICG-VA in intracranial aneurysm surgery. Compared with conventional dye-based angiography, ICG-VA is safer, more effective and more cost-effective. It can assess haemodynamic parameters, cerebral flow during temporary artery occlusion, completeness of clipping and patency of branch vessels. However, implementing ICG-VA in low- and middle-income countries presents challenges such as financial constraints, limited access to training and expertise, patient selection and consent issues. Addressing these obstacles requires capacity-building, training programmes for neurosurgeons and multidisciplinary teams, technology transfer, equipment donations, public-private partnerships, continued research and development, reducing conventional dye usage, reducing ICG wastage, exploring mechanisms to reuse ICG dyes and advocating for increased government funding and healthcare budgets.

摘要

颅内动脉瘤影响着2%-5%的人群,因其可能导致蛛网膜下腔出血和高死亡率,给神经外科医生带来了重大挑战。术中血管造影对于有效的手术规划是必要的,吲哚菁绿视频血管造影(ICG-VA)已成为实时可视化动脉瘤血流的有用工具,有助于更好地规划潜在血流并检测动脉瘤残余。这篇小型叙述性综述探讨了ICG-VA在颅内动脉瘤手术中的应用。与传统的基于染料的血管造影相比,ICG-VA更安全、更有效且更具成本效益。它可以评估血流动力学参数、临时动脉闭塞期间的脑血流、夹闭的完整性和分支血管的通畅性。然而,在低收入和中等收入国家实施ICG-VA存在诸多挑战,如资金限制、培训和专业知识获取有限、患者选择和知情同意问题。解决这些障碍需要能力建设、针对神经外科医生和多学科团队的培训计划、技术转让、设备捐赠、公私伙伴关系、持续的研发、减少传统染料的使用、减少ICG浪费、探索ICG染料再利用机制以及倡导增加政府资金和医疗保健预算。

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Neurosurgery. 2023 Mar 1;92(3):e72-e73. doi: 10.1227/neu.0000000000002330. Epub 2023 Jan 4.
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Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.颅内动脉瘤:病理学、遗传学和分子机制。
Neuromolecular Med. 2019 Dec;21(4):325-343. doi: 10.1007/s12017-019-08537-7. Epub 2019 May 4.

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